Comparison of Novel Martin/Hopkins and Sampson Equations for Calculation of Low-Density Lipoprotein Cholesterol in Diabetic Patients

• Published in: Arquivos brasileiros de cardiologia 2022-01, Vol.119 (2), p.225-233
• Main Authors: Naser, Abdulrahman, Isgandarov, Khagani, Güvenç, Tolga Sinan, Güvenç, Rengin Çetin, Şahin, Müslüm
• Format: Article
• Language: eng ; por
• ISSN: 1678-4170
• DOI: 10.36660/abc.20210641

BACKGROUNDThe accurate determination of low-density lipoprotein cholesterol (LDL-C) is important to reach guideline-recommended LDL-C concentrations and to reduce adverse cardiovascular outcomes in diabetic patients. The commonly used Friedewald equation (LDL-Cf), gives inaccurate results in diabetic patients due to accompanying diabetic dyslipidemia. Recently two new equations - Martin/Hopkins (LDL-Cmh) and Sampson (LDL-Cs) - were developed to improve the accuracy of LDL-C estimation, but data are insufficient to suggest the superiority of one equation over the other one. OBJECTIVEThe present study compared the accuracy and clinical usefulness of novel Martin/Hopkins and Sampson equations in diabetic patients. METHODSThis study included 402 patients with diabetes. Patients' cardiovascular risk and LDL-C targets were calculated per European guidelines. Calculated LDL-Cmh, LDL-Cs, and LDL-Cf concentrations were compared with direct LDL-C concentration (LDL-Cd) to test agreement between these equations and LDL-Cd. A p-value