Implications for pelvic lymph node irradiation in definitive chemoradiotherapy of node negative muscle invasive bladder cancer based on predictive factors of clinicopathologic discrepancy

Purpose To identify pre-surgical imaging predictive value and factors associated with the clinicopathologic discrepancy for implication of definitive pelvic radiotherapy in clinically node-negative bladder cancer. Method The documented data of bladder cancer patients who underwent radical cystectomy...

Full description

Saved in:
Bibliographic Details
Published in:Journal of cancer research and clinical oncology 2023-06, Vol.149 (6), p.2537-2542
Main Authors: Saeedian, Arefeh, Safaei, Afsaneh Maddah, Azimi, Amirali, Kolahdouzan, Kasra, Tabatabaei, Fatemeh-sadat, Esmati, Ebrahim
Format: Article
Language:English
Subjects:
Bladder cancer
Cancer
Cancer Research
Chemoradiotherapy
Chemotherapy
Cystectomy - methods
Hematology
Humans
Internal Medicine
Lymph Node Excision
Lymph nodes
Lymph Nodes - pathology
Lymphatic system
Medicine
Medicine & Public Health
Multivariate analysis
Muscles - pathology
Neoplasm Staging
Oncology
Pathology
Patients
Population studies
Prognosis
Radiation therapy
Retrospective Studies
Survival
Urinary Bladder Neoplasms - pathology
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Purpose To identify pre-surgical imaging predictive value and factors associated with the clinicopathologic discrepancy for implication of definitive pelvic radiotherapy in clinically node-negative bladder cancer. Method The documented data of bladder cancer patients who underwent radical cystectomy plus pelvic lymphadenectomy were collected retrospectively. Patients’ characteristics, last imaging, pathology reports, disease-specific survival and overall survival were retrieved. Results From 142 patients, pre-surgical imaging had a sensitivity of 76.4%, specificity of 73.7%, positive predictive value (PPV) of 94.9%, and negative predictive value (NPV) of 32.6% ( p value 
ISSN:0171-5216
1432-1335
DOI:10.1007/s00432-022-04153-4