Streptocinnamides A and B, Depsipeptides from Streptomyces sp. KMM 9044

The bacterium Streptomyces sp. KMM 9044 from a sample of marine sediment collected in the northwestern part of the Sea of Japan produces highly chlorinated depsiheptapeptides streptocinnamides A (1) and B (2), representatives of a new structural group of antibiotics. The structures of 1 and 2 were d...

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Published in:Organic letters 2022-07, Vol.24 (27), p.4892-4895
Main Authors: Makarieva, Tatyana N., Romanenko, Lyudmila A., Mineev, Konstantin S., Shubina, Larisa K., Guglya, Elena B., Kalinovskaya, Natalia I., Ivanchina, Natalia V., Guzii, Alla G., Belozerova, Olga A., Kovalchuk, Sergey I., Popov, Roman S., Denisenko, Vladimir A., Mikhailov, Valery V., Babenko, Vladislav V., Ilina, Elena N., Malakhova, Maja V., Terekhov, Stanislav S., Kudzhaev, Arsen M., Dmitrenok, Pavel S., Yampolsky, Ilia V., Stonik, Valentin A.
Format: Article
Language:English
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Summary:The bacterium Streptomyces sp. KMM 9044 from a sample of marine sediment collected in the northwestern part of the Sea of Japan produces highly chlorinated depsiheptapeptides streptocinnamides A (1) and B (2), representatives of a new structural group of antibiotics. The structures of 1 and 2 were determined using nuclear magnetic resonance and mass spectrometry studies and confirmed by a series of chemical transformations. Streptocinnamide A potently inhibits Micrococcus sp. KMM 1467, Arthrobacter sp. ATCC 21022, and Mycobacterium smegmatis MC2 155.
ISSN:1523-7060
1523-7052
DOI:10.1021/acs.orglett.2c01714