Synthesis of Unsymmetrical Urea Derivatives via Cu‐Catalyzed Reaction of Acylazide and Secondary Amine

The synthesis of unsymmetrical urea generally requires toxic reagent, solvent and harsh reaction condition. Herein, we introduce Cu‐catalyzed greener and safer unsymmetrical urea derivatives synthesis in ethyl acetate. This method minimized utilization of toxic reagent. A variety of indole, amines,...

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Bibliographic Details
Published in:Chemistry & biodiversity 2022-08, Vol.19 (8), p.e202200346-n/a
Main Authors: Shinde, Jivan, Bhimrao Patil, Prakash, Kavala, Veerababurao, Yao, Ching‐Fa
Format: Article
Language:English
Subjects:
Acetic acid
Amines
copper catalyst
Curtius rearrangement
Ethyl acetate
green solvent
Reagents
unsymmetrical urea
Urea
Ureas
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Summary:The synthesis of unsymmetrical urea generally requires toxic reagent, solvent and harsh reaction condition. Herein, we introduce Cu‐catalyzed greener and safer unsymmetrical urea derivatives synthesis in ethyl acetate. This method minimized utilization of toxic reagent. A variety of indole, amines, and azides with bis‐indole successfully employed leading to high yields and gram scale synthesis of isolated urea.
ISSN:1612-1872
1612-1880
DOI:10.1002/cbdv.202200346