Expression of vascular endothelial growth factor (VEGF) and platelet endothelial cell adhesion molecule (PECAM-1/CD31) in intestinal tuberculosis

•Epithelioid cell granulomas have hypoxic microenvironment acting as a stimulus for angiogenesis.•The significantly increased number of vessels were seen in the granulomatous areas compared to non-granulomatous areas indicating the role of neo-angiogenesis in disease pathogenesis.•VEGF expression wa...

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Published in:Tuberculosis (Edinburgh, Scotland) Scotland), 2022-07, Vol.135, p.102229-102229, Article 102229
Main Authors: More, Shilpi, Wadhwa, Neelam, Jain, Bhupendra K., Mishra, Kiran
Format: Article
Language:English
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Summary:•Epithelioid cell granulomas have hypoxic microenvironment acting as a stimulus for angiogenesis.•The significantly increased number of vessels were seen in the granulomatous areas compared to non-granulomatous areas indicating the role of neo-angiogenesis in disease pathogenesis.•VEGF expression was markedly reduced in the mucosal epithelium of granulomatous area suggesting defective VEGF production by the intestinal epithelium making it prone to injury.•Altered vasculature of the granuloma associated vessels might be a potential therapeutic target for intestinal TB in future, in conjunction with anti-tubercular treatment.
ISSN:1472-9792
1873-281X
DOI:10.1016/j.tube.2022.102229