Causal effect of autoimmune liver diseases on cancer: Meta‐analyses of cohort studies and Mendelian randomization study

Background and Aims Prior studies suggested that patients with autoimmune liver diseases (AiLDs) had an increased risk of cancer, whereas the causal effect remained unclear. Methods Meta‐analyses concerning the relationship between AiLD and cancer risk were performed to calculate the pooled relative...

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Bibliographic Details
Published in:Liver international 2022-10, Vol.42 (10), p.2216-2226
Main Authors: Gu, Dongqing, Zhang, Min, Wang, Yutong, Bai, Ye, Wang, Xin, Deng, Guohong
Format: Article
Language:English
Subjects:
autoimmune hepatitis
autoimmune liver diseases
Cancer
Cholangitis
Cohort analysis
Gastric cancer
Health risks
Hepatitis
Liver
Liver cancer
Liver diseases
Mendelian randomization
Meta-analysis
primary biliary cholangitis
primary sclerosing cholangitis
Randomization
Risk
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Summary:Background and Aims Prior studies suggested that patients with autoimmune liver diseases (AiLDs) had an increased risk of cancer, whereas the causal effect remained unclear. Methods Meta‐analyses concerning the relationship between AiLD and cancer risk were performed to calculate the pooled relative risk (RR) and corresponding 95% confidence intervals (CIs). Then, the associations with a p value of
ISSN:1478-3223
1478-3231
DOI:10.1111/liv.15355