Maintaining soluble protein homeostasis between nuclear and cytoplasmic compartments across mitosis

The nuclear envelope (NE) is central to the architecture of eukaryotic cells, both as a physical barrier separating the nucleus from the cytoplasm and as gatekeeper of selective transport between them. However, in open mitosis, the NE fragments to allow for spindle formation and segregation of chrom...

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Bibliographic Details
Published in:Trends in cell biology 2023-01, Vol.33 (1), p.18-29
Main Authors: van der Zanden, Sabina Y, Jongsma, Marlieke L M, Neefjes, Anna C M, Berlin, Ilana, Neefjes, Jacques
Format: Article
Language:English
Subjects:
Cell Nucleus - metabolism
Cytoplasm - metabolism
Humans
Mitosis
Nuclear Envelope - genetics
Proteostasis
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Summary:The nuclear envelope (NE) is central to the architecture of eukaryotic cells, both as a physical barrier separating the nucleus from the cytoplasm and as gatekeeper of selective transport between them. However, in open mitosis, the NE fragments to allow for spindle formation and segregation of chromosomes, resulting in intermixing of nuclear and cytoplasmic soluble fractions. Recent studies have shed new light on the mechanisms driving reinstatement of soluble proteome homeostasis following NE reformation in daughter cells. Here, we provide an overview of how mitotic cells confront this challenge to ensure continuity of basic cellular functions across generations and elaborate on the implications for the proteasome - a macromolecular machine that functions in both cytoplasmic and nuclear compartments.
ISSN:0962-8924
1879-3088
DOI:10.1016/j.tcb.2022.06.002