Metabolomic Characterization of Acute Ischemic Stroke Facilitates Metabolomic Biomarker Discovery

Acute ischemic stroke (AIS) is characterized by a sudden blockage of one of the main arteries supplying blood to the brain, leading to insufficient oxygen and nutrients for brain cells to function properly. Unfortunately, metabolic alterations in the biofluids with AIS are still not well understood....

Full description

Saved in:
Bibliographic Details
Published in:Applied biochemistry and biotechnology 2022-11, Vol.194 (11), p.5443-5455
Main Authors: Qi, Biao, Zhang, Yanyu, Xu, Bing, Zhang, Yuhao, Fei, Guoqiang, Lin, Ling, Li, Qiuping
Format: Article
Language:English
Subjects:
Arteries
Biochemistry
Biomarkers
Biosynthesis
Biotechnology
Brain
Chemistry
Chemistry and Materials Science
Glucosamine
Ischemia
Lysine
Metabolic pathways
Metabolism
Metabolites
Metabolomics
Multivariate statistical analysis
Nutrients
Original Article
Phenylalanine
Statistical analysis
Stroke
tRNA Lys
Tryptophan
Tyrosine
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Acute ischemic stroke (AIS) is characterized by a sudden blockage of one of the main arteries supplying blood to the brain, leading to insufficient oxygen and nutrients for brain cells to function properly. Unfortunately, metabolic alterations in the biofluids with AIS are still not well understood. In this study, we performed high-throughput target metabolic analysis on 44 serum samples, including 22 from AIS patients and 22 from healthy controls. Multiple-reaction monitoring analysis of 180 common metabolites revealed a total of 29 metabolites that changed significantly (VIP > 1, p  
ISSN:0273-2289
1559-0291
DOI:10.1007/s12010-022-04024-1