The effect of a 9-month hybrid intradialytic exercise training program on nerve conduction velocity parameters in patients receiving hemodialysis therapy

• Published in: International urology and nephrology 2022-12, Vol.54 (12), p.3271-3281
• Main Authors: Grigoriou, Stefania S., Karatzaferi, Christina, Giannaki, Christoforos D., Patramani, Gianna, Vogiatzi, Christina, Mitrou, Georgia I., Stefanidis, Ioannis, Sakkas, Giorgos K.
• Format: Article
• Language: English
• Subjects: Aerobic capacity; Electromyography; End-stage renal disease; Exercise; Fatigue; Fitness training programs; Hemodialysis; Kidney diseases; Latency; Medicine; Medicine & Public Health; Nephrology; Nephrology - Original Paper; Nerve conduction; Neurological complications; Pain; Patients; Peripheral neuropathy; Physical training; Polyneuropathy; Sensory neurons; Sural nerve; Urology; Velocity
• ISSN: 1573-2584; 0301-1623; 1573-2584
• DOI: 10.1007/s11255-022-03266-6

Introduction and aims Neurological complications such as peripheral neuropathy are very common in the end-stage renal disease (ESRD) patients, occurring in 60–80% of this specific population. The aim of the present study was to examine whether a 9-month hybrid intradialytic exercise training program could alter motor and sensory nerve conduction study (NCS) parameters in hemodialysis population. Methods Seventeen stable patients undergoing HD with no clinical evidence of uremic polyneuropathy were included in the study (15 M/2F, 59 ± 13.7 years). All patients completed a 9-month supervised exercise training program composed of both aerobic cycling and resistance training (hybrid) during HD. Functional capacity was assessed by a battery of tests, while pain levels and fatigue profile were assessed via validated questionnaires. Motor and sensory NCS on bilateral median, ulnar, peroneal and tibial nerves as well as F-wave were assessed using a full neurographic electromyography (EMG) assessment. Results After the 9-month exercise training intervention, exercise capacity was increased by 65% and functional capacity by an average of 40%. The neurological assessment showed that conduction velocity from tibial and peroneal nerves was improved by 3.7% and 4.2%, respectively, while tibial F-wave latency and peroneal and sural nerve distal latency were significantly improved by 4.2%, 4.9% and 10%, respectively. Fatigue and pain were improved after the exercise intervention while fatigue score was positively correlated with conduction velocity and amplitude values. Conclusions The results of the current study demonstrate that 9-month hybrid exercise training induces beneficial effects on both sensory and motor NCS parameters, improving conduction velocity and F-wave latency. Improvements in neural activity were accompanied by changes in fatigue score and pain-related aspects. The parallel improvement in motor nerve conduction velocity and its correlations with functional tests supports the hypothesis that exercise could be beneficial for preventing a decline in neural function in HD patients.