Diagnostic and prognostic value of Stanniocalcin 1 expression in papillary thyroid cancer

Purpose To evaluate the potential role of immunohistochemical changes in stanniocalcin 1 (STC1) and stanniocalcin 2 (STC2) expressions in papillary thyroid cancer (PTC) tissues in the disease’s diagnosis and to investigate their relationship with classical clinicopathological prognostic factors. Met...

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Bibliographic Details
Published in:Endocrine 2022-10, Vol.78 (1), p.95-103
Main Authors: Sengun, Sevinç, Korkmaz, Hakan, Ciris, Metin, Yüceer, Ramazan Oguz, Boyluboy, Serife Mehtap, Kiran, Mehmet
Format: Article
Language:English
Subjects:
Diabetes
Diagnosis
Endocrinology
Humanities and Social Sciences
Internal Medicine
Lymph nodes
Lymphatic system
Medical prognosis
Medicine
Medicine & Public Health
Metastases
Metastasis
multidisciplinary
Original Article
Papillary thyroid cancer
Risk factors
Science
Stanniocalcin
Thyroid cancer
Tumors
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Summary:Purpose To evaluate the potential role of immunohistochemical changes in stanniocalcin 1 (STC1) and stanniocalcin 2 (STC2) expressions in papillary thyroid cancer (PTC) tissues in the disease’s diagnosis and to investigate their relationship with classical clinicopathological prognostic factors. Methods The study included 100 patients with PTC. Normal thyroid tissue adjacent to the tumor was taken as the control group. Clinicopathological prognostic features at the time of diagnosis of patients were recorded. STC1 and STC2 expressions of tumor tissue and adjacent normal tissue were determined immunohistochemically. Results The sensitivity of STC1 in the diagnosis of PTC was 93%, the specificity was 94%, positive predictive value (PPV) 93.9%, and negative predictive value (NPV) 93.1%. It was determined that the STC1 staining score in tumor tissue was positively correlated with the disease TNM stage score ( r  = 0.259, p  = 0.009) and the increase in STC1 staining score were independent risk factors that increased the risk of lymph node metastasis ( R 2  = 0.398, p  
ISSN:1559-0100
1355-008X
1559-0100
DOI:10.1007/s12020-022-03126-4