Alternate-day fasting, a high-sucrose/caloric diet and praziquantel treatment influence biochemical and behavioral parameters during Schistosoma mansoni infection in male BALB/c mice

Schistosoma mansoni-induced granulomas result in severe damage to the host's liver, as well as neurological and metabolic disorders. We evaluated the biochemical and behavioral changes during schistosomiasis under three diet protocols: ad libitum (AL), alternate-day fasting (ADF) and a high-suc...

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Published in:Experimental parasitology 2022-09, Vol.240, p.108316-108316, Article 108316
Main Authors: dos Reis, Luis F.C., Cerdeira, Cláudio D., Gagliano, Guilherme S., de Figueiredo, Ana B.T., Ferreira, Juliana H., Castro, Aline P., Souza, Raquel L.M., Marques, Marcos J.
Format: Article
Language:English
Subjects:
Behavioral
Diet
Fasting
Praziquantel
Schistosomiasis
Sucrose
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Summary:Schistosoma mansoni-induced granulomas result in severe damage to the host's liver, as well as neurological and metabolic disorders. We evaluated the biochemical and behavioral changes during schistosomiasis under three diet protocols: ad libitum (AL), alternate-day fasting (ADF) and a high-sucrose/caloric diet (HSD). Healthy male BALB/c mice were divided into noninfected, matched infected and infected/treated [praziquantel (PZQ)] groups. Caloric intake and energy efficiency coefficients associated with diets were measured. Behavioral (exploratory and locomotor) and biochemical (glucose, triglycerides, total cholesterol, AST, ALT, ALP, and γ-GT) tests and histological analysis were performed. Fifteen weeks postinfection, HSD and PZQ promoted weight gain, with higher caloric consumption than ADF (p 
ISSN:0014-4894
1090-2449
DOI:10.1016/j.exppara.2022.108316