GATA3/long noncoding RNA MHC-R regulates the immune activity of dendritic cells in chronic obstructive pulmonary disease induced by air pollution particulate matter

• Published in: Journal of hazardous materials 2022-09, Vol.438, p.129459-129459, Article 129459
• Main Authors: He, Fang, Wang, Nian, Yu, Xiaoyuan, Zheng, Yufan, Liu, Qun, Chen, Qingzi, Pu, Jinding, Li, Naijian, Zou, Weifeng, Li, Bing, Ran, Pixin
• Format: Article
• Language: English
• Subjects: Air pollution PM; COPD; Dendritic cell; GATA3; LncRNA MHC-R
• ISSN: 0304-3894; 1873-3336
• DOI: 10.1016/j.jhazmat.2022.129459

Chronic obstructive pulmonary disease (COPD) is a heterogeneous illness associated with aberrant inflammatory immune reaction in the lung in response to noxious particles and gases. Our previous epidemiological studies discovered that long-term exposure to air pollution PM was associated with an increase in the incidence of COPD and lung function decline, but the impact of air pollution on the onset of COPD and its pathogenesis remains obscure. In recent years, long noncoding RNAs (lncRNAs) have been documented to have a crucial role in COPD. Our preliminary study found that the expression of lncRNA MHC-R in the lung tissues of rats exposed to air pollution PM was dramatically elevated, and the specific expression was mainly focused on the immune-related MHC I, antigen-presenting, and adaptive immune response. After transcription factor prediction, it was found that GATA3 could be combined with the specific sequence of the lncRNA MHC-R promoter region. Dendritic cells (DCs) are necessary antigen-presenting cells (APCs) with the most potent antigen-presenting function. We proved that GATA3/lncRNA MHC-R might regulate the immune activities of DCs to participate in the pathogenic mechanism of COPD induced by air pollution PM, which opens up a new way for early COPD diagnosis and treatment. [Display omitted] •Linking environmental exposures to COPD development and progression.•Upregulation of lncRNA MHC-R in the rat lung after air pollution PM exposure.•Connecting MHC-R with GATA3 to regulate immune dysregulation in PM-related COPD.