Visible-Light-Induced Cascade Cyclization of N‑Propargyl Aromatic Amines and Acyl Oxime Esters: Rapid Access to 3‑Acylated Quinolines

Visible-light-induced radical cascade acylation/cyclization/aromatization of N-propargyl aromatic amines and acyl oxime esters for the construction of 3-acylated quinolines is developed. This approach uses acyl oxime esters as the precursor of acyl radicals as well as acylation reagents, Eosin Y as...

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Bibliographic Details
Published in:Journal of organic chemistry 2022-08, Vol.87 (15), p.10277-10284
Main Authors: Zhang, Man, Wu, Sixin, Wang, Lei, Xia, Ziqin, Kuang, Kaimo, Xu, Qiankun, Zhao, Fangli, Zhou, Nengneng
Format: Article
Language:English
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Summary:Visible-light-induced radical cascade acylation/cyclization/aromatization of N-propargyl aromatic amines and acyl oxime esters for the construction of 3-acylated quinolines is developed. This approach uses acyl oxime esters as the precursor of acyl radicals as well as acylation reagents, Eosin Y as the photocatalyst, and acetonitrile as the solvent, providing a convenient route toward 3-acylated quinolines via the C–C bond cleavage of acyl oxime esters.
ISSN:0022-3263
1520-6904
DOI:10.1021/acs.joc.2c01277