Efficacy and Safety of Ultrafiltration in Patients with Heart Failure: A Single-Center Experience

Introduction There is a paucity of literature on the efficacy and safety of ultrafiltration in Chinese patients with heart failure (HF). Therefore, we aimed to compare the efficacy and safety of ultrafiltration with diuretics and provide information and evidence as to the best approach for patients...

Full description

Saved in:
Bibliographic Details
Published in:Advances in therapy 2022-10, Vol.39 (10), p.4523-4532
Main Authors: Xiangli, Shen, Lan, Li, Libiya, Zu, Jun, Ma, Shubin, Jiang
Format: Article
Language:English
Subjects:
Cardiology
Creatinine
Diuretics - therapeutic use
Dyspnea - therapy
Endocrinology
Heart Failure - therapy
Humans
Internal Medicine
Medicine
Medicine & Public Health
Oncology
Original Research
Pharmacology/Toxicology
Potassium
Rheumatology
Sodium
Ultrafiltration - methods
Weight Loss
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Introduction There is a paucity of literature on the efficacy and safety of ultrafiltration in Chinese patients with heart failure (HF). Therefore, we aimed to compare the efficacy and safety of ultrafiltration with diuretics and provide information and evidence as to the best approach for patients with HF. Methods In this single-center, non-randomized interventional study patients with HF either received diuretics or ultrafiltration. The efficacy outcomes included changes in the weight, dyspnea score, and 6-min walk distance from baseline to 48 h after treatment. Safety outcomes were evaluated in both the groups with respect to changes in systolic blood pressure, heart rate, serum creatinine, blood urea nitrogen, blood potassium ion concentration, and blood sodium ion concentration. Results A total of 149 patients with HF (diuretics, 73; ultrafiltration, 76) were included. At 48 h, patients in the ultrafiltration group showed significantly greater weight loss and better improvement in dyspnea score and 6-min walk distance compared to patients in the control group ( P  
ISSN:0741-238X
1865-8652
DOI:10.1007/s12325-022-02227-w