Successful eradication of chronic myeloid leukemia in a child despite allogeneic graft rejection

BACKGROUNDChronic myeloid leukemia (CML) is a rare disease in children and treated with tyrosine kinase inhibitors (TKI) and with allogeneic hematopoietic stem cell transplantation (HSCT) still in many cases. CASEWe describe an 8-year-old patient with CML treated with two different TKIs before proce...

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Bibliographic Details
Published in:Cancer reports (Hoboken, N.J.) N.J.), 2022, Vol.5 (10), p.e1663-e1663
Main Authors: Vuorenoja, Susanna, Vettenranta, Kim, Lohi, Olli
Format: Report
Language:English
Online Access:Get full text
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Summary:BACKGROUNDChronic myeloid leukemia (CML) is a rare disease in children and treated with tyrosine kinase inhibitors (TKI) and with allogeneic hematopoietic stem cell transplantation (HSCT) still in many cases. CASEWe describe an 8-year-old patient with CML treated with two different TKIs before proceeding to allogeneic HSCT. Despite successful engraftment, prompt rejection of the graft was followed by autologous reconstitution. TKI therapy was reintroduced post-rejection in anticipation of relapse but shortly discontinued due to low white blood cell and neutrophil counts. The patient has remained disease-free over 5 years after graft rejection and without further therapy. CONCLUSIONThis case suggests that even a short antileukemic effect by an allogeneic transplant may succeed in eradicating CML.
ISSN:2573-8348
DOI:10.1002/cnr2.1663