Total Synthesis and Structural Elucidation of Ogipeptins

The first total synthesis of ogipeptin A was achieved. Recently, using the advanced Marfey’s method, we determined the absolute configuration patterns of three β-hydroxy-α,γ-diaminobutyric acids (β-OH Dabs) composing ogipeptins. On the basis of this result, we conducted solid-phase total synthesis o...

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Bibliographic Details
Published in:Organic letters 2022-07, Vol.24 (27), p.4935-4938
Main Authors: Takiguchi, Shingo, Hirota-Takahata, Yuki, Nishi, Takahide
Format: Article
Language:English
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Summary:The first total synthesis of ogipeptin A was achieved. Recently, using the advanced Marfey’s method, we determined the absolute configuration patterns of three β-hydroxy-α,γ-diaminobutyric acids (β-OH Dabs) composing ogipeptins. On the basis of this result, we conducted solid-phase total synthesis of three diastereomers of ogipeptin A. The analytical data of one diastereomer exactly corresponded with those of natural ogipeptin A. Therefore, the absolute configurations of ogipeptins have been elucidated.
ISSN:1523-7060
1523-7052
DOI:10.1021/acs.orglett.2c01863