Antibody and T-Cell Responses 6 Months After Coronavirus Disease 2019 Messenger RNA-1273 Vaccination in Patients With Chronic Kidney Disease, on Dialysis, or Living With a Kidney Transplant

Abstract Background The immune response to COVID-19 vaccination is inferior in kidney transplant recipients (KTRs) and to a lesser extent in patients on dialysis or with chronic kidney disease (CKD). We assessed the immune response 6 months after mRNA-1273 vaccination in kidney patients and compared...

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Published in:Clinical infectious diseases 2023-02, Vol.76 (3), p.e188-e199
Main Authors: Sanders, Jan-Stephan F, Messchendorp, A Lianne, de Vries, Rory D, Baan, Carla C, van Baarle, Debbie, van Binnendijk, Rob, Diavatopoulos, Dimitri A, Geers, Daryl, Schmitz, Katharina S, GeurtsvanKessel, Corine H, den Hartog, Gerco, Kho, Marcia M L, Koopmans, Marion P G, van der Molen, Renate G, Remmerswaal, Ester B M, Rots, Nynke, Gansevoort, Ron T, Bemelman, Frederike J, Hilbrands, Luuk B, Reinders, Marlies E J
Format: Article
Language:English
Subjects:
Antibodies, Neutralizing
Antibodies, Viral
COVID-19 - prevention & control
COVID-19 Vaccines
Humans
Immunoglobulin G
Kidney Transplantation
Renal Dialysis
Renal Insufficiency, Chronic - therapy
SARS-CoV-2
T-Lymphocytes
Vaccination
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Summary:Abstract Background The immune response to COVID-19 vaccination is inferior in kidney transplant recipients (KTRs) and to a lesser extent in patients on dialysis or with chronic kidney disease (CKD). We assessed the immune response 6 months after mRNA-1273 vaccination in kidney patients and compared this to controls. Methods A total of 152 participants with CKD stages G4/5 (eGFR
ISSN:1058-4838
1537-6591
1537-6591
DOI:10.1093/cid/ciac557