A bioprintable gellan gum/lignin hydrogel: a smart and sustainable route for cartilage regeneration

In this work a hydrogel, based on a blend of two gellan gums with different acyl content embedding lignin (up to 0.4%w/v) and crosslinked with magnesium ions, was developed for cartilage regeneration. The physico-chemical characterizations established that no chemical interaction between lignin and...

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Bibliographic Details
Published in:International journal of biological macromolecules 2022-09, Vol.216, p.336-346
Main Authors: Bonifacio, Maria A., Cometa, Stefania, Cochis, Andrea, Scalzone, Annachiara, Gentile, Piergiorgio, Scalia, Alessandro C., Rimondini, Lia, Mastrorilli, Piero, De Giglio, Elvira
Format: Article
Language:English
Subjects:
Bioink
Gellan gum
Lignin
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Summary:In this work a hydrogel, based on a blend of two gellan gums with different acyl content embedding lignin (up to 0.4%w/v) and crosslinked with magnesium ions, was developed for cartilage regeneration. The physico-chemical characterizations established that no chemical interaction between lignin and polysaccharides was detected. Lignin achieved up to 80 % of ascorbic acid's radical scavenging activity in vitro on DPPH and ABTS radicals. Viability of hMSC onto hydrogel containing lignin resulted comparable to the lignin-free one (>70 % viable cells, p > 0.05). The presence of lignin improved the hMSC 3D-constructs chondrogenesis, bringing to a significant (p 
ISSN:0141-8130
1879-0003
DOI:10.1016/j.ijbiomac.2022.07.002