Distinct biochemical properties of the class I histone deacetylase complexes

Classical histone deacetylases (HDACs) are enzymes that can hydrolytically cleave acetyl-Lys in histones and other proteins and serve as established drug targets in some forms of cancer. Class I HDACs 1–3 typically exist in a range of multiprotein complexes inside cells and show distinct biological...

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Published in:Current opinion in chemical biology 2022-10, Vol.70, p.102179, Article 102179
Main Authors: Lee, Kwangwoon, Whedon, Samuel D., Wang, Zhipeng A., Cole, Philip A.
Format: Article
Language:English
Subjects:
Histone Deacetylase Inhibitors
Histone Deacetylases - metabolism
Histones - chemistry
Multiprotein Complexes
Nucleosomes
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description Classical histone deacetylases (HDACs) are enzymes that can hydrolytically cleave acetyl-Lys in histones and other proteins and serve as established drug targets in some forms of cancer. Class I HDACs 1–3 typically exist in a range of multiprotein complexes inside cells and show distinct biological functions in modulating gene expression. In recent years, it has become possible to purify and analyze the structure and enzymatic properties of several of these HDAC complexes, including CoREST, MiDAC, NuRD, Sin3, SMRT, MIER, and RERE. Here, we summarize what is experimentally established and/or computationally predicted about the structure of these complexes to describe their particular catalytic activities and site-specificities with modified nucleosome substrates.
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subjects Histone Deacetylase Inhibitors
Histone Deacetylases - metabolism
Histones - chemistry
Multiprotein Complexes
Nucleosomes
title Distinct biochemical properties of the class I histone deacetylase complexes
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