Industrial production of L-lysine in Corynebacterium glutamicum: Progress and prospects

L-lysine is one of the amino acids necessary for humans and animals and widely used in food processing, pharmaceutical preparations and feed additives. In recent years, rational design based on systems metabolic engineering and conventional optimization of fermentation parameters have contributed to...

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Bibliographic Details
Published in:Microbiological research 2022-09, Vol.262, p.127101-127101, Article 127101
Main Authors: Liu, Jie, Xu, Jian-Zhong, Rao, Zhi-Ming, Zhang, Wei-Guo
Format: Article
Language:English
Subjects:
Corynebacterium glutamicum
Downstream processing
Fermentation optimization
L-lysine
Systems metabolic engineering
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Summary:L-lysine is one of the amino acids necessary for humans and animals and widely used in food processing, pharmaceutical preparations and feed additives. In recent years, rational design based on systems metabolic engineering and conventional optimization of fermentation parameters have contributed to the high production of L-lysine. As the demand for L-lysine in the world market is increasing year by year, intensive research has been devoted to efficient productivity and economic production costs. This review briefly explains the biosynthesis and regulation mechanism of L-lysine in Corynebacterium glutamicum, and then outlines the construction, scale-up culture, and product separation and purification strategies of L-lysine high-producing strains. In addition, emerging strategies for the breeding and fermentation of C. glutamicum for the production of L-lysine have been emphatically elucidated. In short, the commercialization of L-lysine production requires chassis strains with excellent production performance, efficient fermentation process, and the development of sustainable purification technologies. •A comprehensive description of the industrial process of Corynebacterium glutamicum producing L-lysine.•A series of directed evolution, dynamic regulation and high-throughput screening strategies based on transcriptional regulatory factors and riboswitches.•Use raw materials that do not compete with humans to replace traditional carbon sources to ferment to produce L-lysine.•Realize the joint production of L-lysine and high value-added metabolites.
ISSN:0944-5013
1618-0623
DOI:10.1016/j.micres.2022.127101