Breaking down a gut-to-brain circuit that prevents malabsorption

The ileal brake is an important reflex that ensures proper absorption of nutrients. This involves intestinal GLP-1 release, which recruits an enteric-sympathetic-spinal pathway to inhibit gastric motility and appetite. This visceral alarm system could be targeted to treat obesity and gastrointestina...

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Bibliographic Details
Published in:Cell 2022-07, Vol.185 (14), p.2393-2395
Main Authors: Jarvie, Brooke C, Knight, Zachary A
Format: Article
Language:English
Subjects:
Brain
Gastrointestinal Diseases
Glucagon-Like Peptide 1
Humans
Ileum
Obesity
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Summary:The ileal brake is an important reflex that ensures proper absorption of nutrients. This involves intestinal GLP-1 release, which recruits an enteric-sympathetic-spinal pathway to inhibit gastric motility and appetite. This visceral alarm system could be targeted to treat obesity and gastrointestinal dysfunction.
ISSN:0092-8674
1097-4172
DOI:10.1016/j.cell.2022.06.012