Early histological changes of bronchopulmonary dysplasia and pulmonary hypertension may precede clinical diagnosis in preterm infants

AbstractBronchopulmonary Dysplasia (BPD), the commonest complication of prematurity, is defined by treatment with oxygen for ≥28 days. Pulmonary hypertension (PH) often coexists with BPD and is associated with increased mortality. In 42 autopsies, histological changes of BPD and PH were demonstrated...

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Bibliographic Details
Published in:Early human development 2022-08, Vol.171, p.105612-105612, Article 105612
Main Authors: Stone, Amelia, Poulik, Janet, Koussa, Sara, Xin, Yuemin, Sharma, Amit, Sood, Beena G
Format: Article
Language:English
Subjects:
Advanced Basic Science
Neonatal and Perinatal Medicine
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Summary:AbstractBronchopulmonary Dysplasia (BPD), the commonest complication of prematurity, is defined by treatment with oxygen for ≥28 days. Pulmonary hypertension (PH) often coexists with BPD and is associated with increased mortality. In 42 autopsies, histological changes of BPD and PH were demonstrated in 25 % and 65 % respectively of preterm infants
ISSN:0378-3782
1872-6232
DOI:10.1016/j.earlhumdev.2022.105612