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Amygdala Metabotropic Glutamate Receptor 1 Influences Synaptic Transmission to Participate in Fentanyl-Induced Hyperalgesia in Rats
The underlying mechanisms of opioid-induced hyperalgesia (OIH) remain unclear. Herein, we found that the protein expression of metabotropic glutamate receptor 1 (mGluR1) was significantly increased in the right but not in the left laterocapsular division of central nucleus of the amygdala (CeLC) in...
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| Published in: | Cellular and molecular neurobiology 2023-04, Vol.43 (3), p.1401-1412 |
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| creator | Bai, Tianyu Chen, Hengling Hu, Wenwu Liu, Jingtao Lin, Xianguang Chen, Su Luo, Fang Yang, Xiaofei Chen, Jun Li, Chenhong |
| description | The underlying mechanisms of opioid-induced hyperalgesia (OIH) remain unclear. Herein, we found that the protein expression of metabotropic glutamate receptor 1 (mGluR1) was significantly increased in the right but not in the left laterocapsular division of central nucleus of the amygdala (CeLC) in OIH rats. In CeLC neurons, the frequency and the amplitude of mini-excitatory postsynaptic currents (mEPSCs) were significantly increased in fentanyl group which were decreased by acute application of a mGluR1 antagonist, A841720. Finally, the behavioral hypersensitivity could be reversed by A841720 microinjection into the right CeLC. These results show that the right CeLC mGluR1 is an important factor associated with OIH that enhances synaptic transmission and could be a potential drug target to alleviate fentanyl-induced hyperalgesia.
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| doi_str_mv | 10.1007/s10571-022-01248-x |
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Graphical Abstract</description><subject>Amygdala</subject><subject>Amygdala - metabolism</subject><subject>Analgesics, Opioid - pharmacology</subject><subject>Animals</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Brief Communication</subject><subject>Cell Biology</subject><subject>Excitatory postsynaptic potentials</subject><subject>Fentanyl</subject><subject>Glutamic acid receptors (metabotropic)</subject><subject>Hyperalgesia</subject><subject>Hyperalgesia - chemically induced</subject><subject>Microinjection</subject><subject>Neurobiology</subject><subject>Neurosciences</subject><subject>Pain perception</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Receptors, Metabotropic Glutamate - metabolism</subject><subject>Synaptic Transmission</subject><subject>Therapeutic targets</subject><issn>0272-4340</issn><issn>1573-6830</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><recordid>eNp9kU1rFTEUhoMo9rb6B1xIwI2b0XxOkmUptr1QUWpdh9zkzGXKTGZMMtBZ-8fN7a0KLlwFTp73PQcehN5Q8oESoj5mSqSiDWGsIZQJ3Tw8QxsqFW9azclztCFMsUZwQU7Qac73hBBDiHyJTrhURhvONujn-bjugxsc_gzF7aaSprn3-GpYihtdAXwLHuYyJUzxNnbDAtFDxt_W6OZSwbvkYh77nPsp4jLhry7VcT8fon3ElxCLi-vQbGNYPAR8vc6Q3LCH3LsDcOtKfoVedG7I8PrpPUPfLz_dXVw3N1-uthfnN43nSpbGUEPbEKg30guinOZcip1xnNSxdp2gwUjBOghCCiNAgQydDho4bb0klJ-h98feOU0_FsjF1sM9DIOLMC3ZslYrxVrOdEXf_YPeT0uK9TrLlJZty7XklWJHyqcp5wSdnVM_urRaSuxBkT0qslWRfVRkH2ro7VP1shsh_In8dlIBfgRy_Yp7SH93_6f2FysrnaQ</recordid><startdate>20230401</startdate><enddate>20230401</enddate><creator>Bai, Tianyu</creator><creator>Chen, Hengling</creator><creator>Hu, Wenwu</creator><creator>Liu, Jingtao</creator><creator>Lin, Xianguang</creator><creator>Chen, Su</creator><creator>Luo, Fang</creator><creator>Yang, Xiaofei</creator><creator>Chen, Jun</creator><creator>Li, Chenhong</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-9598-8191</orcidid><orcidid>https://orcid.org/0000-0003-1569-4730</orcidid><orcidid>https://orcid.org/0000-0001-6234-6048</orcidid><orcidid>https://orcid.org/0000-0002-9312-4306</orcidid><orcidid>https://orcid.org/0000-0001-8129-2188</orcidid><orcidid>https://orcid.org/0000-0001-5922-6344</orcidid><orcidid>https://orcid.org/0000-0002-4875-0877</orcidid><orcidid>https://orcid.org/0000-0003-4103-5712</orcidid><orcidid>https://orcid.org/0000-0001-8383-2432</orcidid><orcidid>https://orcid.org/0000-0003-1028-0846</orcidid></search><sort><creationdate>20230401</creationdate><title>Amygdala Metabotropic Glutamate Receptor 1 Influences Synaptic Transmission to Participate in Fentanyl-Induced Hyperalgesia in Rats</title><author>Bai, Tianyu ; 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Herein, we found that the protein expression of metabotropic glutamate receptor 1 (mGluR1) was significantly increased in the right but not in the left laterocapsular division of central nucleus of the amygdala (CeLC) in OIH rats. In CeLC neurons, the frequency and the amplitude of mini-excitatory postsynaptic currents (mEPSCs) were significantly increased in fentanyl group which were decreased by acute application of a mGluR1 antagonist, A841720. Finally, the behavioral hypersensitivity could be reversed by A841720 microinjection into the right CeLC. These results show that the right CeLC mGluR1 is an important factor associated with OIH that enhances synaptic transmission and could be a potential drug target to alleviate fentanyl-induced hyperalgesia.
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| subjects | Amygdala Amygdala - metabolism Analgesics, Opioid - pharmacology Animals Biomedical and Life Sciences Biomedicine Brief Communication Cell Biology Excitatory postsynaptic potentials Fentanyl Glutamic acid receptors (metabotropic) Hyperalgesia Hyperalgesia - chemically induced Microinjection Neurobiology Neurosciences Pain perception Rats Rats, Sprague-Dawley Receptors, Metabotropic Glutamate - metabolism Synaptic Transmission Therapeutic targets |
| title | Amygdala Metabotropic Glutamate Receptor 1 Influences Synaptic Transmission to Participate in Fentanyl-Induced Hyperalgesia in Rats |
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