Pharmacokinetics of lanoconazole in human skin after repeated topical application

Drug disposition after topical application to the skin has not been fully elucidated, especially after repeated application. We conducted a clinical trial to evaluate the pharmacokinetics in the stratum corneum of healthy adults after repeated application of lanoconazole cream as a model drug. We ap...

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Bibliographic Details
Published in:Journal of dermatology 2022-11, Vol.49 (11), p.1118-1123
Main Authors: Imai, Hiromitsu, Hashimoto, Satoru, Ninomiya, Ryo, Luo, Jingna, Wakuda, Hirokazu, Otani, Naoyuki, Inoue, Genta, Amagishi, Hiroaki, Uemura, Naoto
Format: Article
Language:English
Subjects:
dermato‐pharmacokinetics
Lanoconazole
Mass spectroscopy
Pharmacokinetics
repeated topical application
Stratum corneum
Topical application
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Summary:Drug disposition after topical application to the skin has not been fully elucidated, especially after repeated application. We conducted a clinical trial to evaluate the pharmacokinetics in the stratum corneum of healthy adults after repeated application of lanoconazole cream as a model drug. We applied 25 mg of 1% lanoconazole cream onto the pre‐specified areas on the participants' back once daily for 5 days. The stratum corneum was sampled twice on each study day using a standardized tape‐stripping method, and the amount of lanoconazole contained in the samples was quantified using the tandem mass spectrometry method. The obtained data were used to evaluate lanoconazole pharmacokinetics in the stratum corneum. The amount of lanoconazole in the stratum corneum after once daily repeated administration reached a steady state on day 3, and it was eliminated from the stratum corneum with a half‐life of approximately 11 h after discontinuing application.
ISSN:0385-2407
1346-8138
DOI:10.1111/1346-8138.16515