Cross-resistance between macrocyclic lactones in populations of Rhipicephalus microplus in Brazil’s semiarid region

Rhipicephalus microplus , also known as the cattle tick, is the parasite with the greatest impact on cattle in Brazil. The most common method for controlling this tick is the application of synthetic chemical acaricides, especially ivermectin, which belongs to the group of macrocyclic lactones (MLs)...

Full description

Saved in:
Bibliographic Details
Published in:Experimental & applied acarology 2022-05, Vol.87 (1), p.109-117
Main Authors: Ferreira, Larissa Claudino, Lima, Estefany Ferreira, Silva, Ana Luzia Peixoto, Oliveira, Clarisse Silva Menezes, Silva Filho, Geraldo Moreira, Sousa, Luana Carneiro, Klafke, Guilherme Marcondes, Feitosa, Thais Ferreira, Vilela, Vinícius Longo Ribeiro
Format: Article
Language:English
Subjects:
Acaricides
Animal Ecology
Animal Genetics and Genomics
Animal Systematics/Taxonomy/Biogeography
Bioassays
Biomedical and Life Sciences
Cattle
Control methods
Cross-resistance
Drug resistance
Ectoparasites
Eggs
Entomology
Epidemiology
Farms
Humidity
Ivermectin
Laboratories
Lactones
Life Sciences
Parasites
Parasitology
Populations
Rhipicephalus microplus
Semi arid areas
Semiarid lands
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Rhipicephalus microplus , also known as the cattle tick, is the parasite with the greatest impact on cattle in Brazil. The most common method for controlling this tick is the application of synthetic chemical acaricides, especially ivermectin, which belongs to the group of macrocyclic lactones (MLs). However, because ivermectin is widely used, there is concern about the development of cross-resistance within this chemical class. Thus, engorged females were collected from farms with a history of resistance to ivermectin, which was the only one among the MLs that was used as an endectocide drug. Using larval immersion tests (LIT), bioassays were performed with ivermectin, moxidectin and eprinomectin on populations of R. microplus from the semiarid region of the states of Paraíba and Ceará, Brazil. Epidemiological questionnaires were applied to collect information about tick control management. All the evaluated populations showed cross-resistance between ivermectin and moxidectin, but only one population showed cross-resistance between ivermectin and eprinomectin. Weekly or monthly administration of injectable 1% ivermectin on farms was reported. It was concluded that the frequent use of ivermectin may lead to the development of cross-resistance to moxidectin. For eprinomectin, despite the structural similarity, cross-resistance was not observed in three tick populations.
ISSN:0168-8162
1572-9702
DOI:10.1007/s10493-022-00730-x