Micrococcin P2 Targets Clostridioides difficile

Clostridioides difficile infection is a global public health threat. Extensive in vitro assays using clinical isolates have identified micrococcin P2 (MP2, 1) as a particularly effective anti-C. difficile agent. MP2 possesses a mode of action that differs from other antibiotics and pharmacokinetic p...

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Bibliographic Details
Published in:Journal of natural products (Washington, D.C.) D.C.), 2022-08, Vol.85 (8), p.1928-1935
Main Authors: Son, Young-Jin, Kim, Young-Rok, Oh, Sang-Hun, Jung, Sungji, Ciufolini, Marco A., Hwang, Hee-Jong, Kwak, Jin-Hwan, Pai, Hyunjoo
Format: Article
Language:English
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Summary:Clostridioides difficile infection is a global public health threat. Extensive in vitro assays using clinical isolates have identified micrococcin P2 (MP2, 1) as a particularly effective anti-C. difficile agent. MP2 possesses a mode of action that differs from other antibiotics and pharmacokinetic properties that render it especially promising. Its time–kill studies have been investigated using hypervirulent C. difficile ribotype 027. DSS (dextran sulfate sodium)-induced in vivo mouse studies with that strain indicate that 1 is better than vancomycin and fidaxomicin. Thus, micrococcin P2 is a valuable platform to be exploited for the development of new anti-C. difficile antibiotics.
ISSN:0163-3864
1520-6025
DOI:10.1021/acs.jnatprod.2c00120