Promoting Nerve Regeneration: Electrical Stimulation, Gene Therapy, and Beyond

Peripheral nerve injuries often result in life-altering functional deficits even with optimal management. Unlike the central nervous system, peripheral nerves have the ability to regenerate lost axons after injury; however, axonal regeneration does not equate to full restoration of function. To over...

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Bibliographic Details
Published in:Physiology (Bethesda, Md.) Md.), 2022-11, Vol.37 (6), p.0-310
Main Authors: O'Brien, Andrew L, West, Julie M, Saffari, Tiam M, Nguyen, Minh, Moore, Amy M
Format: Article
Language:English
Subjects:
Axons - physiology
Electric Stimulation - methods
Genetic Therapy
Humans
Nerve Regeneration - physiology
Peripheral Nerve Injuries - therapy
Peripheral Nerves - physiology
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Summary:Peripheral nerve injuries often result in life-altering functional deficits even with optimal management. Unlike the central nervous system, peripheral nerves have the ability to regenerate lost axons after injury; however, axonal regeneration does not equate to full restoration of function. To overcome this physiological shortcoming, advances in nerve regeneration and repair are paramount, including electrical stimulation, gene therapy, and surgical technique advancements.
ISSN:1548-9213
1548-9221
DOI:10.1152/physiol.00008.2022