Recent advances in sonodynamic immunotherapy

Tumor immunotherapy has become an important means of tumor therapy by enhancing the immune response and triggering the activation of immune cells. However, currently, only a small number of patients respond to immunotherapy alone, and patients may experience immune-related adverse events (irAEs) dur...

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Bibliographic Details
Published in:Journal of cancer research and clinical oncology 2023-04, Vol.149 (4), p.1645-1656
Main Authors: Du, Jia-Rui, Wang, Yang, Yue, Zong-Hua, Zhang, Han-Yu, Wang, Hui, Sui, Guo-Qing, Sun, Zhi-Xia
Format: Article
Language:English
Subjects:
Antigens
Apoptosis
Cancer Research
Cancer therapies
Cell activation
Cell Line, Tumor
Chemotherapy
Combined Modality Therapy
Cytotoxicity
Dendritic cells
Hematology
Humans
Hypoxia
Immune response
Immune system
Immunotherapy
Immunotherapy - adverse effects
Internal Medicine
Medical research
Medicine
Medicine & Public Health
Metastasis
Nanoparticles
Neoplasms - therapy
Oncology
Photodynamic therapy
Radiation therapy
Reactive Oxygen Species
Review
Tumors
Ultrasonic imaging
Ultrasonic Therapy
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Summary:Tumor immunotherapy has become an important means of tumor therapy by enhancing the immune response and triggering the activation of immune cells. However, currently, only a small number of patients respond to immunotherapy alone, and patients may experience immune-related adverse events (irAEs) during the course of treatment. Sonodynamic therapy (SDT) can produce cytotoxic substances to tumor tissue, induce apoptosis and enhance immunity. SDT combined with immunotherapy is considered a promising strategy for cancer treatment. In this mini review, we summarize the role of SDT in immunotherapy in recent years, including the application of SDT-triggered immunotherapy and the combination of SDT and immunotherapy.
ISSN:0171-5216
1432-1335
DOI:10.1007/s00432-022-04190-z