Predictive value of macular ganglion cell-inner plexiform layer thickness in visual field defect of pituitary adenoma patients: a case-control study

• Published in: Pituitary 2022-08, Vol.25 (4), p.667-672
• Main Authors: Xia, Li, Wenhui, Jia, Xiaowen, Yang, Wenfang, Xie, Wei, Zhang, Yanjun, Hu, Xiaoyan, Peng
• Format: Article
• Language: English
• Subjects: Adenoma; Endocrinology; Eye; Human Physiology; Medicine; Medicine & Public Health; Neurosurgery; Patients; Pituitary; Risk factors; Surgery; Tumors; Visual field
• ISSN: 1386-341X; 1573-7403
• DOI: 10.1007/s11102-022-01248-6

Objective The present study explored the association between preoperative macular ganglion cell-inner plexiform layer thickness (GCIPL) and retinal nerve fiber layer thickness (RNFL) measured by optical coherence tomography (OCT) and the recovery of visual field (VF) defect after surgery in pituitary adenoma patients. Methods This case-control study included patients with pituitary adenoma in the Neurosurgery Department of Shanxi Provincial People’s Hospital between October 2019 and June 2021. Cranial MRI examination, three-dimensional OCT, and VF testing (Humphrey Field Analyzer II750) were performed before and at 6months after the surgery. Results Fifty-three pituitary adenoma patients (81 eyes) were enrolled; 15 patients (23 eyes) were in the visual field did not recover group (VFNR), and 38 patients (58 eyes) were in the visual field recovered group (VFR). The temporal RNFL (P = 0.002) and average RNFL (P = 0.009) in the VFNR group were significantly lower than in the VFR group. The superior nasal GCIPL (P = 0.001), inferior nasal GCIPL (P = 0.001) and average GCIPL (P = 0.01) were significantly lower in the VFNR group than in the VFR group (all P