Synchronization of Cocrystal Dissolution and Drug Precipitation to Sustain Drug Supersaturation

A graphical analysis of both drug and coformer concentrations contributed by dissolving cocrystals is presented in the context of a simplified cocrystal phase diagram. The conceptual basis and analysis identify parameters that control cocrystal dissolution–drug supersaturation–precipitation (DSP) be...

Full description

Saved in:
Bibliographic Details
Published in:Molecular pharmaceutics 2022-08, Vol.19 (8), p.2765-2775
Main Authors: Cogo Machado, Tatiane, Kavanagh, Oisín N., Gonçalves Cardoso, Simone, Rodríguez-Hornedo, Naír
Format: Article
Language:English
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:A graphical analysis of both drug and coformer concentrations contributed by dissolving cocrystals is presented in the context of a simplified cocrystal phase diagram. The conceptual basis and analysis identify parameters that control cocrystal dissolution–drug supersaturation–precipitation (DSP) behavior. The important effects of coformer concentration, cocrystal dose, and cocrystal solubility on drug supersaturation levels are demonstrated and quantified by the DSPindex. While the studies presented rely on high and nonstoichiometric coformer concentrations contributed by the dissolving cocrystals, the concepts and findings can answer the question of whether and how much coformer should be added to cocrystal dissolution media or formulations.
ISSN:1543-8384
1543-8392
DOI:10.1021/acs.molpharmaceut.2c00122