In vitro evaluation of the bioadhesive properties of hydrophobic polybasic gels containing \+i\N,\-i\\+i\N\-i\-dimethylaminoethyl methacrylate-co-methyl methacrylate

The bioadhesive properties of hydrophobic, basic polyelectrolyte hydrogel disks containing cross-linked N,N-dimethylaminoethyl methacrylate-co-methyl methacrylate 30/70 mol% were evaluated in vitro, using gastric (pH 1.2), sublingual (pH 6.5), vaginal (pH 4.0) and intestinal (pH 7.5) pig's muco...

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Bibliographic Details
Published in:Biomaterials 2001-05, Vol.22 (9), p.957-961
Main Authors: Quintanar-Guerrero, D, Villalobos-Garcia |h R., Alvarez-Colin |h E., Cornejo-Bravo |h J. M.
Format: Article
Language:English
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Summary:The bioadhesive properties of hydrophobic, basic polyelectrolyte hydrogel disks containing cross-linked N,N-dimethylaminoethyl methacrylate-co-methyl methacrylate 30/70 mol% were evaluated in vitro, using gastric (pH 1.2), sublingual (pH 6.5), vaginal (pH 4.0) and intestinal (pH 7.5) pig's mucosa. The adhesive strength increased with increasing cross-linker content, in the pH range 4.0-7.5; but the opposite was observed at pH 4.0-1.2. The results indicate that hydrophobic polybasic gels present bioadhesive properties that make them suitable for site-specific, pH-controlled drug delivery. (Original abstract - amended)
ISSN:0142-9612