Serum Ang-1/Ang-2 ratio may be a promising biomarker for evaluating severity of diabetic retinopathy

Purpose To investigate the predictive role of serum angiopoietin-1 and angiopoietin-2 (Ang-1/Ang-2) in evaluating the severity of diabetic retinopathy (DR). Methods A total of 101 outpatients with type 2 diabetes mellitus (T2DM) were recruited and were further divided into the following five groups:...

Full description

Saved in:
Bibliographic Details
Published in:Graefe's archive for clinical and experimental ophthalmology 2023, Vol.261 (1), p.49-55
Main Authors: Wang, Yihan, Fang, Junwei, Niu, Tian, Xing, Xindan, Wang, Hanying, Shi, Xin, Liu, Yujuan, Liu, Xinyi, Chen, Chong, Liu, Kun
Format: Article
Language:English
Subjects:
Angiopoietin
Angiopoietin-1
Biomarkers
Diabetes
Diabetes mellitus (non-insulin dependent)
Diabetes Mellitus, Type 2 - complications
Diabetes Mellitus, Type 2 - diagnosis
Diabetic retinopathy
Diabetic Retinopathy - diagnosis
Humans
Medicine
Medicine & Public Health
Ophthalmology
Retinal Disorders
Retinopathy
ROC Curve
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Purpose To investigate the predictive role of serum angiopoietin-1 and angiopoietin-2 (Ang-1/Ang-2) in evaluating the severity of diabetic retinopathy (DR). Methods A total of 101 outpatients with type 2 diabetes mellitus (T2DM) were recruited and were further divided into the following five groups: T2DM without DR (non-DR), mild non-proliferative DR (NPDR), moderate NPDR, severe NPDR and proliferative DR (PDR) in accordance with the International Clinical Diabetic Retinopathy Guidelines. Furthermore, 101 serum samples were included in the further analysis using enzyme-linked immunosorbent assays. A receiver operating characteristic (ROC) curve was plotted to evaluate the diagnostic value of each index. Results The expression of Ang-1 in the PDR group was significantly lower than that in the non-DR group, while Ang-2 showed an opposite upward trend ( p  
ISSN:0721-832X
1435-702X
DOI:10.1007/s00417-022-05745-z