Survival analyses of soft tissue pleomorphic sarcomas and a proposed leiomyosarcoma-specific dynamic nomogram: A large population-based study

• Published in: Pathology, research and practice research and practice, 2022-09, Vol.237, p.153999-153999, Article 153999
• Main Authors: Le, Minh-Khang, Oishi, Naoki, Vuong, Huy Gia, Kondo, Tetsuo
• Format: Article
• Language: English
• Subjects: Dynamic nomogram; Leiomyosarcoma; Pleomorphic sarcoma; Prognosis; SEER; Soft tissue sarcoma
• ISSN: 0344-0338; 1618-0631
• DOI: 10.1016/j.prp.2022.153999

Pleomorphic sarcoma of soft tissue11PSST: pleomorphic sarcoma of soft tissue (PSST) is a heterogeneous group of sarcomas with different prognoses. Survival patterns of this tumor group have not been thoroughly investigated. Prognostic models should be developed to support individualized evaluation of PSST patients. We collected cases of soft tissue tumors in the Surveillance, Epidemiology, and End Results22SEER: Surveillance, Epidemiology, and End Results (SEER) database, excluding tumors located in intra-abdominal and retroperitoneal regions. We included patients with histopathologic diagnoses of tumors in the PSST group (n = 14,685) and compared the survival patterns of the different histologic types. To develop a prognostic model of leiomyosarcoma, we divided leiomyosarcoma patients into two groups. The first group (n = 4136) was patients with missing values, which became our training cohort after imputation. The second group (n = 671) was the validation cohort. Leiomyosarcoma was the most common PSST (32.7 %). By pairwise comparison, we found that histologic types of PSST can be divided into 4 prognostic groups (p