Patient ABO blood type is a major predictor of a positive DAT following a transfusion reaction

Background A direct antiglobulin test (DAT) checks for antibody or complement on the surface of RBCs and is often done following a transfusion reaction. While passive anti‐A and anti‐B antibodies are known to cause positive DATs, the extent this occurs following transfusion is unknown. Study Design...

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Bibliographic Details
Published in:Transfusion (Philadelphia, Pa.) Pa.), 2022-09, Vol.62 (9), p.1715-1719
Main Authors: Schnieders, Eric, Leon, Judith, Chapman, James M., Knudson, C. Michael
Format: Article
Language:English
Subjects:
ABO system
Antibodies
Blood
Blood groups
Blood products
Compatibility
Coombs' test
DAT
Incompatibility
Patients
Plasma
Product information
Transfusion
transfusion reactions
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Summary:Background A direct antiglobulin test (DAT) checks for antibody or complement on the surface of RBCs and is often done following a transfusion reaction. While passive anti‐A and anti‐B antibodies are known to cause positive DATs, the extent this occurs following transfusion is unknown. Study Design and Methods DAT results, ABO type, eluate information, and blood product information were recorded on 1097 transfusion reactions at a large academic hospital over 8 years. The effect of patient blood type, product type, and plasma compatibility of blood product transfused on DAT results were determined. Statistical significance was determined using Chi‐squared testing. Results Patient ABO blood type was a strong predictor of a positive DAT, with type O patients having 6.7% positive rate and non‐O patients having a positive rate of 20.6% (p 
ISSN:0041-1132
1537-2995
DOI:10.1111/trf.17019