Patient ABO blood type is a major predictor of a positive DAT following a transfusion reaction

Background A direct antiglobulin test (DAT) checks for antibody or complement on the surface of RBCs and is often done following a transfusion reaction. While passive anti‐A and anti‐B antibodies are known to cause positive DATs, the extent this occurs following transfusion is unknown. Study Design...

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Published in:Transfusion (Philadelphia, Pa.) Pa.), 2022-09, Vol.62 (9), p.1715-1719
Main Authors: Schnieders, Eric, Leon, Judith, Chapman, James M., Knudson, C. Michael
Format: Article
Language:English
Subjects:
ABO system
Antibodies
Blood
Blood groups
Blood products
Compatibility
Coombs' test
DAT
Incompatibility
Patients
Plasma
Product information
Transfusion
transfusion reactions
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container_title Transfusion (Philadelphia, Pa.)
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creator Schnieders, Eric
Leon, Judith
Chapman, James M.
Knudson, C. Michael
description Background A direct antiglobulin test (DAT) checks for antibody or complement on the surface of RBCs and is often done following a transfusion reaction. While passive anti‐A and anti‐B antibodies are known to cause positive DATs, the extent this occurs following transfusion is unknown. Study Design and Methods DAT results, ABO type, eluate information, and blood product information were recorded on 1097 transfusion reactions at a large academic hospital over 8 years. The effect of patient blood type, product type, and plasma compatibility of blood product transfused on DAT results were determined. Statistical significance was determined using Chi‐squared testing. Results Patient ABO blood type was a strong predictor of a positive DAT, with type O patients having 6.7% positive rate and non‐O patients having a positive rate of 20.6% (p 
doi_str_mv 10.1111/trf.17019
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Michael</creator><creatorcontrib>Schnieders, Eric ; Leon, Judith ; Chapman, James M. ; Knudson, C. Michael</creatorcontrib><description>Background A direct antiglobulin test (DAT) checks for antibody or complement on the surface of RBCs and is often done following a transfusion reaction. While passive anti‐A and anti‐B antibodies are known to cause positive DATs, the extent this occurs following transfusion is unknown. Study Design and Methods DAT results, ABO type, eluate information, and blood product information were recorded on 1097 transfusion reactions at a large academic hospital over 8 years. The effect of patient blood type, product type, and plasma compatibility of blood product transfused on DAT results were determined. Statistical significance was determined using Chi‐squared testing. Results Patient ABO blood type was a strong predictor of a positive DAT, with type O patients having 6.7% positive rate and non‐O patients having a positive rate of 20.6% (p &lt; .0001). Plasma compatibility of the product was a strong predictor of a positive DAT, with plasma compatible transfusions having a 9.4% positive rate while plasma incompatible transfusions were positive 44% of the time (p &lt; .0001). Elution studies found that anti‐A/B antibodies were the most common antibody identified. Platelets were more likely to be associated with a positive DAT when compared with RBC transfusions (p &lt; .05). Conclusions These results demonstrate the patient ABO type and plasma incompatibility are strong predictors of positive DAT results following a transfusion reaction. Anti‐A and anti‐B antibodies are estimated to account for about 50% of positive DATs in this study.</description><identifier>ISSN: 0041-1132</identifier><identifier>EISSN: 1537-2995</identifier><identifier>DOI: 10.1111/trf.17019</identifier><language>eng</language><publisher>Hoboken, USA: John Wiley &amp; Sons, Inc</publisher><subject>ABO system ; Antibodies ; Blood ; Blood groups ; Blood products ; Compatibility ; Coombs' test ; DAT ; Incompatibility ; Patients ; Plasma ; Product information ; Transfusion ; transfusion reactions</subject><ispartof>Transfusion (Philadelphia, Pa.), 2022-09, Vol.62 (9), p.1715-1719</ispartof><rights>2022 AABB.</rights><rights>2022 AABB</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c2559-c9748841fb7ed28c4fdc98320fe6985941f6ee12ee2f160d95e055104d02fa723</cites><orcidid>0000-0003-3964-5466</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids></links><search><creatorcontrib>Schnieders, Eric</creatorcontrib><creatorcontrib>Leon, Judith</creatorcontrib><creatorcontrib>Chapman, James M.</creatorcontrib><creatorcontrib>Knudson, C. Michael</creatorcontrib><title>Patient ABO blood type is a major predictor of a positive DAT following a transfusion reaction</title><title>Transfusion (Philadelphia, Pa.)</title><description>Background A direct antiglobulin test (DAT) checks for antibody or complement on the surface of RBCs and is often done following a transfusion reaction. While passive anti‐A and anti‐B antibodies are known to cause positive DATs, the extent this occurs following transfusion is unknown. Study Design and Methods DAT results, ABO type, eluate information, and blood product information were recorded on 1097 transfusion reactions at a large academic hospital over 8 years. The effect of patient blood type, product type, and plasma compatibility of blood product transfused on DAT results were determined. Statistical significance was determined using Chi‐squared testing. Results Patient ABO blood type was a strong predictor of a positive DAT, with type O patients having 6.7% positive rate and non‐O patients having a positive rate of 20.6% (p &lt; .0001). Plasma compatibility of the product was a strong predictor of a positive DAT, with plasma compatible transfusions having a 9.4% positive rate while plasma incompatible transfusions were positive 44% of the time (p &lt; .0001). Elution studies found that anti‐A/B antibodies were the most common antibody identified. Platelets were more likely to be associated with a positive DAT when compared with RBC transfusions (p &lt; .05). Conclusions These results demonstrate the patient ABO type and plasma incompatibility are strong predictors of positive DAT results following a transfusion reaction. Anti‐A and anti‐B antibodies are estimated to account for about 50% of positive DATs in this study.</description><subject>ABO system</subject><subject>Antibodies</subject><subject>Blood</subject><subject>Blood groups</subject><subject>Blood products</subject><subject>Compatibility</subject><subject>Coombs' test</subject><subject>DAT</subject><subject>Incompatibility</subject><subject>Patients</subject><subject>Plasma</subject><subject>Product information</subject><subject>Transfusion</subject><subject>transfusion reactions</subject><issn>0041-1132</issn><issn>1537-2995</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><recordid>eNp1kE9LAzEQxYMoWKsHv0HAix5WJ-lmd3Osf6pCoSL1aoi7E0nZbtYka-m3N1pPgnOZYd5vHsMj5JTBJUt1Fb25ZCUwuUdGTEzKjEsp9skIIGcZYxN-SI5CWAEAl8BG5PVJR4tdpNPrBX1rnWto3PZIbaCarvXKedp7bGwd0-RMWvYu2Gg_kd5Ol9S4tnUb270nIXrdBTME6zrqUdcxDcfkwOg24MlvH5OX2d3y5iGbL-4fb6bzrOZCyKyWZV5VOTNvJTa8qnPT1LKacDBYyErIpBSIjCNywwpopEAQgkHeADe65JMxOd_59t59DBiiWttQY9vqDt0QFC8kA8EhLxJ69gdducF36TvFS8YBpKi-DS92VO1dCB6N6r1da79VDNR30iolrX6STuzVjt3YFrf_g2r5PNtdfAGSgH4r</recordid><startdate>202209</startdate><enddate>202209</enddate><creator>Schnieders, Eric</creator><creator>Leon, Judith</creator><creator>Chapman, James M.</creator><creator>Knudson, C. Michael</creator><general>John Wiley &amp; Sons, Inc</general><general>Wiley Subscription Services, Inc</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7U9</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>P64</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-3964-5466</orcidid></search><sort><creationdate>202209</creationdate><title>Patient ABO blood type is a major predictor of a positive DAT following a transfusion reaction</title><author>Schnieders, Eric ; Leon, Judith ; Chapman, James M. ; Knudson, C. Michael</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2559-c9748841fb7ed28c4fdc98320fe6985941f6ee12ee2f160d95e055104d02fa723</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>ABO system</topic><topic>Antibodies</topic><topic>Blood</topic><topic>Blood groups</topic><topic>Blood products</topic><topic>Compatibility</topic><topic>Coombs' test</topic><topic>DAT</topic><topic>Incompatibility</topic><topic>Patients</topic><topic>Plasma</topic><topic>Product information</topic><topic>Transfusion</topic><topic>transfusion reactions</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Schnieders, Eric</creatorcontrib><creatorcontrib>Leon, Judith</creatorcontrib><creatorcontrib>Chapman, James M.</creatorcontrib><creatorcontrib>Knudson, C. Michael</creatorcontrib><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Transfusion (Philadelphia, Pa.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Schnieders, Eric</au><au>Leon, Judith</au><au>Chapman, James M.</au><au>Knudson, C. Michael</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Patient ABO blood type is a major predictor of a positive DAT following a transfusion reaction</atitle><jtitle>Transfusion (Philadelphia, Pa.)</jtitle><date>2022-09</date><risdate>2022</risdate><volume>62</volume><issue>9</issue><spage>1715</spage><epage>1719</epage><pages>1715-1719</pages><issn>0041-1132</issn><eissn>1537-2995</eissn><abstract>Background A direct antiglobulin test (DAT) checks for antibody or complement on the surface of RBCs and is often done following a transfusion reaction. While passive anti‐A and anti‐B antibodies are known to cause positive DATs, the extent this occurs following transfusion is unknown. Study Design and Methods DAT results, ABO type, eluate information, and blood product information were recorded on 1097 transfusion reactions at a large academic hospital over 8 years. The effect of patient blood type, product type, and plasma compatibility of blood product transfused on DAT results were determined. Statistical significance was determined using Chi‐squared testing. Results Patient ABO blood type was a strong predictor of a positive DAT, with type O patients having 6.7% positive rate and non‐O patients having a positive rate of 20.6% (p &lt; .0001). Plasma compatibility of the product was a strong predictor of a positive DAT, with plasma compatible transfusions having a 9.4% positive rate while plasma incompatible transfusions were positive 44% of the time (p &lt; .0001). Elution studies found that anti‐A/B antibodies were the most common antibody identified. Platelets were more likely to be associated with a positive DAT when compared with RBC transfusions (p &lt; .05). Conclusions These results demonstrate the patient ABO type and plasma incompatibility are strong predictors of positive DAT results following a transfusion reaction. Anti‐A and anti‐B antibodies are estimated to account for about 50% of positive DATs in this study.</abstract><cop>Hoboken, USA</cop><pub>John Wiley &amp; Sons, Inc</pub><doi>10.1111/trf.17019</doi><tpages>5</tpages><orcidid>https://orcid.org/0000-0003-3964-5466</orcidid><oa>free_for_read</oa></addata></record>
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source Wiley
subjects ABO system
Antibodies
Blood
Blood groups
Blood products
Compatibility
Coombs' test
DAT
Incompatibility
Patients
Plasma
Product information
Transfusion
transfusion reactions
title Patient ABO blood type is a major predictor of a positive DAT following a transfusion reaction
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