Physical activity and antibody persistence 6 months after the second dose of CoronaVac in immunocompromised patients

• Published in: Scandinavian journal of medicine & science in sports 2022-10, Vol.32 (10), p.1510-1515
• Main Authors: Gualano, Bruno, Lemes, Ítalo Ribeiro, Silva, Rafael Pires, Pinto, Ana Jéssica, Mazzolani, Bruna Caruso, Smaira, Fabiana Infante, Sieczkowska, Sofia Mendes, Aikawa, Nádia Emi, Pasoto, Sandra, Medeiros‐Ribeiro, Ana Cristina, Saad, Carla, Yuk, Emily, Silva, Clovis, Swinton, Paul, Hallal, Pedro Curi, Roschel, Hamilton, Bonfa, Eloisa
• Format: Article
• Language: English
• Subjects: autoimmune rheumatic disease; COVID‐19; Drug dosages; Exercise; immunosuppression; physical activity; vaccine responses
• ISSN: 0905-7188; 1600-0838
• DOI: 10.1111/sms.14213

This prospective cohort study within an open‐label, single‐arm, phase 4 vaccination trial (clinicaltrials.gov #NCT04754698) aimed to investigate the association between physical activity and persistent anti‐SARS‐CoV‐2 antibodies 6 months after two‐dose schedule of CoronaVac in autoimmune rheumatic diseases (ARD) patients (n = 748). Persistent immunogenicity 6 months after the full‐course vaccination was assessed using seroconversion rates of total anti‐SARS‐CoV‐2 S1/S2 IgG, geometric mean titers of anti‐S1/S2 IgG (GMT), and frequency of positive neutralizing antibodies (NAb). Physical activity was assessed trough questionnaire. Adjusted point estimates from logistic regression models indicated that physically active patients had greater odds of seroconversion rates (OR: 1.5 [95%CI: 1.1 to 2.1]) and NAb positivity (OR: 1.5 [95%CI: 1.0 to 2.1]), and approximately 43% greater GMT (42.8% [95%CI: 11.9 to 82.2]) than inactive ones. In conclusion, among immunocompromised patients, being physically active was associated with an increment in antibody persistence through 6 months after a full‐course of an inactivated SARS‐CoV‐2 vaccine.