Impact of small dense low-density lipoprotein cholesterol on cholesterol crystals in patients with acute coronary syndrome: An optical coherence tomography study

• Published in: Journal of clinical lipidology 2022-07, Vol.16 (4), p.438-446
• Main Authors: Sekimoto, Teruo, Koba, Shinji, Mori, Hiroyoshi, Arai, Taito, Matsukawa, Naoki, Sakai, Rikuo, Yokota, Yuya, Sato, Shunya, Tanaka, Hideaki, Masaki, Ryota, Oishi, Yosuke, Ogura, Kunihiro, Arai, Ken, Nomura, Kosuke, Sakai, Koshiro, Tsujita, Hiroaki, Kondo, Seita, Tsukamoto, Shigeto, Matsumoto, Hidenari, Suzuki, Hiroshi, Shinke, Toshiro
• Format: Article
• Language: English
• Subjects: Acute coronary syndrome; Cholesterol crystals; Optical coherence tomography; Small dense low-density lipoprotein cholesterol
• ISSN: 1933-2874; 1876-4789
• DOI: 10.1016/j.jacl.2022.04.008

•Sd-LDL-c was an independent risk factor of cholesterol crystals (CC).•The levels of sd-LDL-c, apolipoprotein C3, and HbA1c were associated with CC.•The presence of CC is associated with vulnerable plaques, such as ruptured plaques.•A negative correlation was found between sd-LDL-c levels and CC-depth.•Sd-LDL-c increased significantly with increased macrophage grade. The presence of cholesterol crystals (CCs) is recognized as a component of vulnerable atherosclerotic plaques at risk of rupture. The phagocytosis of atherogenic lipid factors by macrophages precedes and promotes the formation of vulnerable plaques, but it is not clear how these factors affect the formation of CC. This study aimed to evaluate the relationship between lipid biomarkers such as small dense low-density lipoprotein cholesterol (sd-LDL-c) and CC detected by optical coherence tomography (OCT) in patients with acute coronary syndrome (ACS). Serum samples were collected immediately before coronary angiography in consecutive 174 patients with ACS who did not take statins and underwent OCT imaging of the culprit lesion. The sd-LDL-c levels were measured using a direct homogenous assay. CC was defined as a thin linear structure with high reflectivity and low signal attenuation on the OCT images. CC was identified in 85 patients (48.9%). The prevalence of CC was significantly higher in lesions with ruptured plaques and greater macrophage grade. The sd-LDL-c levels were significantly higher in the patients with CC (41.6 vs. 31.2 mg/dL, p = 0.01) although there were no significant differences in the levels of LDL-c and apolipoprotein B. The CC group also had higher levels of apolipoprotein C3 and HbA1c levels. In multiple logistic regression analysis, sd-LDL-c was an independent risk factor of CC (odds ratio, 1.19 per 10 mg/dL; p = 0.03). sd-LDL may play an important role in the presence of CC in patients with ACS. [Display omitted]