Model of Osteomyelitis in Rats

We developed a rat model of chronic osteomyelitis of the femur caused by Staphylococcus aureus . The clinical, histomorphological, and laboratory signs were compared in rats with osteomyelitis (infected) and control animals receiving saline. On day 21 after infection, clinical, histomorphological, a...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2022-07, Vol.173 (3), p.394-397
Main Authors: Ovchinnikov, E. N., Dyuryagina, O. V., Stogov, M. V., Silanteva, T. A., Kireeva, E. A.
Format: Article
Language:English
Subjects:
Biomedical and Life Sciences
Biomedicine
Cell Biology
Chronic infection
Connective tissue
Experiments
Femur
Health aspects
Hematology
Internal Medicine
Laboratory animals
Laboratory Medicine
Medical research
Orthopedics
Osteomyelitis
Pathology
Rodents
Skin
Staphylococcus aureus infections
Surgery
Wire
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Description
Summary:We developed a rat model of chronic osteomyelitis of the femur caused by Staphylococcus aureus . The clinical, histomorphological, and laboratory signs were compared in rats with osteomyelitis (infected) and control animals receiving saline. On day 21 after infection, clinical, histomorphological, and laboratory signs of chronic osteomyelitis were found in experimental rats.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-022-05556-6