Diagnostic value of Serum Amyloid A, Interleukin-6 in gravidas with spontaneous preterm birth

• Published in: Clinica chimica acta 2022-09, Vol.534, p.77-80
• Main Authors: Zuo, Luguang, Xu, Yuhuan, Du, Shuai, Li, Xiaoying, Zhao, Tong, Zhang, Yuhong, Liu, Zhenkui, Li, Shutie
• Format: Article
• Language: English
• Subjects: Diagnostic value; Interleukin-6; Risk prediction; Serum Amyloid A; Spontaneous preterm birth
• ISSN: 0009-8981; 1873-3492
• DOI: 10.1016/j.cca.2022.07.008

[Display omitted] •Nowadays, the clinical medical community has not been able to accurately predict spontaneous preterm birth, which threatens the life safety of many pregnant women and fetuses.•SAA and IL-6 were representative index in different mechanisms of the body, and are closely related to the mechanism and causes of preterm birth.•This study aims to study the application of SAA and IL-6 in predicting spontaneous preterm birth, and provides theoretical support for clinicians to evaluate the risk of spontaneous preterm birth. Spontaneous preterm birth (SPB) can’t be predicted accurately nowadays. We aim to investigate the value of serum amyloid A(SAA) and interleukin-6(IL-6) for forecasting the risk of SPB. A total of 302 pregnant women who completed delivery in our hospital from January 2019 to December 2021 were included. According to gestational days, they were divided into the case group (28–33+6 weeks, 41 cases; 34–36+6 weeks, 96 cases) and the control group (37–42 weeks, 165 cases). The general data of the two groups were analyzed and the values of SAA and IL-6 in speculating the risk of SPB were studied in this study. The levels of SAA and IL-6 in the case group were higher than those in the control group(P