The possible beneficial impacts of evodiamine on hepatotoxicity induced by cisplatin

In this, it was aimed to determine the possible beneficial effects of evodiamine on hepatotoxicity induced by experimental cisplatin administration in rats. For this purpose, experimental animals were divided into four groups ( n =6). Groups were designed as control, evodiamine (EVO), cisplatin (CIS...

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Published in:Environmental science and pollution research international 2022-12, Vol.29 (59), p.89522-89529
Main Authors: Akdemir, Fazile Nur Ekinci, Yıldırım, Serkan, Kandemir, Fatih Mehmet
Format: Article
Language:English
Subjects:
Anesthesia
Animals
Antigens
Antioxidants
Apoptosis
Aquatic Pollution
Atmospheric Protection/Air Quality Control/Air Pollution
Biochemistry
Caspase-8
Chemotherapy
Cisplatin
Drug dosages
Earth and Environmental Science
Ecotoxicology
Environment
Environmental Chemistry
Environmental Health
Environmental science
Enzymatic activity
Enzymes
Experiments
Hepatotoxicity
Laboratories
Lipid peroxidation
Lipids
Liver
Medical research
Microwaves
Oxidative stress
Pathology
Peroxidation
Research Article
Tumor necrosis factor-α
Waste Water Technology
Water Management
Water Pollution Control
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Summary:In this, it was aimed to determine the possible beneficial effects of evodiamine on hepatotoxicity induced by experimental cisplatin administration in rats. For this purpose, experimental animals were divided into four groups ( n =6). Groups were designed as control, evodiamine (EVO), cisplatin (CIS), and evodiamine+cisplatin (EVO+CIS) groups. All experimental processes were applied according to rules of ethical. Rats were sacrificed by high-dose anesthesia. Considering the biochemical results of this study, it can be said that lipid peroxidation level increased and antioxidant enzyme activities decreased in the CIS group comparing to control and only EVO groups. But in the EVO+CIS group, antioxidant activities increased and lipid peroxidation decreased. Moreover, immunohistochemically caspase 8 and TNF-α expressions were severe in the CIS group, whereas, in the EVO+CIS group, these expressions attenuated. According to all our findings, it can be expressed that evodiamine has beneficial effects against hepatotoxicity induced by experimental cisplatin administration Graphical abstract
ISSN:0944-1344
1614-7499
DOI:10.1007/s11356-022-22007-x