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The possible beneficial impacts of evodiamine on hepatotoxicity induced by cisplatin
In this, it was aimed to determine the possible beneficial effects of evodiamine on hepatotoxicity induced by experimental cisplatin administration in rats. For this purpose, experimental animals were divided into four groups ( n =6). Groups were designed as control, evodiamine (EVO), cisplatin (CIS...
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| Published in: | Environmental science and pollution research international 2022-12, Vol.29 (59), p.89522-89529 |
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| container_title | Environmental science and pollution research international |
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| creator | Akdemir, Fazile Nur Ekinci Yıldırım, Serkan Kandemir, Fatih Mehmet |
| description | In this, it was aimed to determine the possible beneficial effects of evodiamine on hepatotoxicity induced by experimental cisplatin administration in rats. For this purpose, experimental animals were divided into four groups (
n
=6). Groups were designed as control, evodiamine (EVO), cisplatin (CIS), and evodiamine+cisplatin (EVO+CIS) groups. All experimental processes were applied according to rules of ethical. Rats were sacrificed by high-dose anesthesia. Considering the biochemical results of this study, it can be said that lipid peroxidation level increased and antioxidant enzyme activities decreased in the CIS group comparing to control and only EVO groups. But in the EVO+CIS group, antioxidant activities increased and lipid peroxidation decreased. Moreover, immunohistochemically caspase 8 and TNF-α expressions were severe in the CIS group, whereas, in the EVO+CIS group, these expressions attenuated. According to all our findings, it can be expressed that evodiamine has beneficial effects against hepatotoxicity induced by experimental cisplatin administration
Graphical abstract |
| doi_str_mv | 10.1007/s11356-022-22007-x |
| format | article |
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n
=6). Groups were designed as control, evodiamine (EVO), cisplatin (CIS), and evodiamine+cisplatin (EVO+CIS) groups. All experimental processes were applied according to rules of ethical. Rats were sacrificed by high-dose anesthesia. Considering the biochemical results of this study, it can be said that lipid peroxidation level increased and antioxidant enzyme activities decreased in the CIS group comparing to control and only EVO groups. But in the EVO+CIS group, antioxidant activities increased and lipid peroxidation decreased. Moreover, immunohistochemically caspase 8 and TNF-α expressions were severe in the CIS group, whereas, in the EVO+CIS group, these expressions attenuated. According to all our findings, it can be expressed that evodiamine has beneficial effects against hepatotoxicity induced by experimental cisplatin administration
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n
=6). Groups were designed as control, evodiamine (EVO), cisplatin (CIS), and evodiamine+cisplatin (EVO+CIS) groups. All experimental processes were applied according to rules of ethical. Rats were sacrificed by high-dose anesthesia. Considering the biochemical results of this study, it can be said that lipid peroxidation level increased and antioxidant enzyme activities decreased in the CIS group comparing to control and only EVO groups. But in the EVO+CIS group, antioxidant activities increased and lipid peroxidation decreased. Moreover, immunohistochemically caspase 8 and TNF-α expressions were severe in the CIS group, whereas, in the EVO+CIS group, these expressions attenuated. According to all our findings, it can be expressed that evodiamine has beneficial effects against hepatotoxicity induced by experimental cisplatin administration
Graphical abstract</description><subject>Anesthesia</subject><subject>Animals</subject><subject>Antigens</subject><subject>Antioxidants</subject><subject>Apoptosis</subject><subject>Aquatic Pollution</subject><subject>Atmospheric Protection/Air Quality Control/Air Pollution</subject><subject>Biochemistry</subject><subject>Caspase-8</subject><subject>Chemotherapy</subject><subject>Cisplatin</subject><subject>Drug dosages</subject><subject>Earth and Environmental Science</subject><subject>Ecotoxicology</subject><subject>Environment</subject><subject>Environmental Chemistry</subject><subject>Environmental Health</subject><subject>Environmental science</subject><subject>Enzymatic activity</subject><subject>Enzymes</subject><subject>Experiments</subject><subject>Hepatotoxicity</subject><subject>Laboratories</subject><subject>Lipid peroxidation</subject><subject>Lipids</subject><subject>Liver</subject><subject>Medical research</subject><subject>Microwaves</subject><subject>Oxidative stress</subject><subject>Pathology</subject><subject>Peroxidation</subject><subject>Research Article</subject><subject>Tumor necrosis factor-α</subject><subject>Waste Water Technology</subject><subject>Water Management</subject><subject>Water Pollution Control</subject><issn>0944-1344</issn><issn>1614-7499</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>M0C</sourceid><recordid>eNp9kE1LxDAQhoMouH78AU8BL16qySQ27VEWv2DBy3oOaTpxs7RNbVrZ_fdGKwgevMzA8Lwvw0PIBWfXnDF1EzkXt3nGADKAdMh2B2TBcy4zJcvykCxYKWXGhZTH5CTGLWPASlALsl5vkPYhRl81SCvs0HnrTUN92xs7RhocxY9Qe9P6Dmno6AZ7M4Yx7BI37qnv6sliTas9tT72jRl9d0aOnGkinv_sU_L6cL9ePmWrl8fn5d0qs1DAmCazlSoKFJV0XLkapCldqdAK65Qo0hkFVFKhtBZKZxyXgjuhKl6gU7k4JVdzbz-E9wnjqFsfLTaN6TBMUUNeAlMgC5HQyz_oNkxDl77ToIQCxTjIRMFM2SEpGdDpfvCtGfaaM_0lWs-idRKtv0XrXQqJORQT3L3h8Fv9T-oT2m2CAw</recordid><startdate>20221201</startdate><enddate>20221201</enddate><creator>Akdemir, Fazile Nur 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possible beneficial impacts of evodiamine on hepatotoxicity induced by cisplatin</title><author>Akdemir, Fazile Nur Ekinci ; Yıldırım, Serkan ; Kandemir, Fatih Mehmet</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c282t-c20cb788e3b4f17fd24a9f97ec3cf7383b4e32b47e4cc29faf1431f37b18ef763</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Anesthesia</topic><topic>Animals</topic><topic>Antigens</topic><topic>Antioxidants</topic><topic>Apoptosis</topic><topic>Aquatic Pollution</topic><topic>Atmospheric Protection/Air Quality Control/Air Pollution</topic><topic>Biochemistry</topic><topic>Caspase-8</topic><topic>Chemotherapy</topic><topic>Cisplatin</topic><topic>Drug dosages</topic><topic>Earth and Environmental Science</topic><topic>Ecotoxicology</topic><topic>Environment</topic><topic>Environmental Chemistry</topic><topic>Environmental Health</topic><topic>Environmental 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Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Environmental science and pollution research international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Akdemir, Fazile Nur Ekinci</au><au>Yıldırım, Serkan</au><au>Kandemir, Fatih Mehmet</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The possible beneficial impacts of evodiamine on hepatotoxicity induced by cisplatin</atitle><jtitle>Environmental science and pollution research international</jtitle><stitle>Environ Sci Pollut Res</stitle><date>2022-12-01</date><risdate>2022</risdate><volume>29</volume><issue>59</issue><spage>89522</spage><epage>89529</epage><pages>89522-89529</pages><issn>0944-1344</issn><eissn>1614-7499</eissn><abstract>In this, it was aimed to determine the possible beneficial effects of evodiamine on hepatotoxicity induced by experimental cisplatin administration in rats. For this purpose, experimental animals were divided into four groups (
n
=6). Groups were designed as control, evodiamine (EVO), cisplatin (CIS), and evodiamine+cisplatin (EVO+CIS) groups. All experimental processes were applied according to rules of ethical. Rats were sacrificed by high-dose anesthesia. Considering the biochemical results of this study, it can be said that lipid peroxidation level increased and antioxidant enzyme activities decreased in the CIS group comparing to control and only EVO groups. But in the EVO+CIS group, antioxidant activities increased and lipid peroxidation decreased. Moreover, immunohistochemically caspase 8 and TNF-α expressions were severe in the CIS group, whereas, in the EVO+CIS group, these expressions attenuated. According to all our findings, it can be expressed that evodiamine has beneficial effects against hepatotoxicity induced by experimental cisplatin administration
Graphical abstract</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><doi>10.1007/s11356-022-22007-x</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0003-2457-3367</orcidid><orcidid>https://orcid.org/0000-0002-8490-2479</orcidid></addata></record> |
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| ispartof | Environmental science and pollution research international, 2022-12, Vol.29 (59), p.89522-89529 |
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| subjects | Anesthesia Animals Antigens Antioxidants Apoptosis Aquatic Pollution Atmospheric Protection/Air Quality Control/Air Pollution Biochemistry Caspase-8 Chemotherapy Cisplatin Drug dosages Earth and Environmental Science Ecotoxicology Environment Environmental Chemistry Environmental Health Environmental science Enzymatic activity Enzymes Experiments Hepatotoxicity Laboratories Lipid peroxidation Lipids Liver Medical research Microwaves Oxidative stress Pathology Peroxidation Research Article Tumor necrosis factor-α Waste Water Technology Water Management Water Pollution Control |
| title | The possible beneficial impacts of evodiamine on hepatotoxicity induced by cisplatin |
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