Fecal calprotectin as a biomarker of microscopic bowel inflammation in patients with spondyloarthritis

Aim Microscopic bowel inflammation is present in up to 60% of all patients with spondyloarthritis (SpA) and appears to be associated with more severe joint disease and a higher risk of developing inflammatory bowel disease (IBD). This study aimed to determine the utility of fecal calprotectin (fCAL)...

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Published in:International journal of rheumatic diseases 2022-09, Vol.25 (9), p.1078-1086
Main Authors: Campos, Júlia Faria, Resende, Gustavo Gomes, Barbosa, Alfredo José Afonso, Carvalho, Silas Castro, Lage, Junia Aguiar, Cunha, Pedro Ferrari Sales, Souza, Stela Cristina Silva, Ferrari, Maria de Lourdes Abreu
Format: Article
Language:English
Subjects:
ankylosing spondylitis
Arthritis
biomarker
Biopsy
Endoscopy
fecal calprotectin
Inflammation
inflammatory bowel disease
Inflammatory bowel diseases
Inflammatory diseases
Intestine
Joint diseases
Nonsteroidal anti-inflammatory drugs
Rheumatic diseases
spondyloarthritis
Statistical analysis
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Summary:Aim Microscopic bowel inflammation is present in up to 60% of all patients with spondyloarthritis (SpA) and appears to be associated with more severe joint disease and a higher risk of developing inflammatory bowel disease (IBD). This study aimed to determine the utility of fecal calprotectin (fCAL) in evaluating endoscopic and histological bowel inflammation in SpA patients. Methods Ileocolonoscopies with biopsies and fCAL measurements were performed in 65 patients with SpA. Results In 47 (72.3%) patients, the fCAL levels were higher than 50 μg/g, whereas in 20 (30.7%), these levels were greater than 250 μg/g. A total of 38 (58.5%) patients presented with microscopic bowel inflammation, and 13 (20%) presented with signs of endoscopic inflammation. fCAL levels were significantly higher in patients with microscopic bowel inflammation than in those without inflammatory findings (P 
ISSN:1756-1841
1756-185X
DOI:10.1111/1756-185X.14388