Garcicowanones C-E, three new hydrated-geranylated xanthones from the roots of Garcinia cowa Roxb. ex Choisy, and their α-glucosidase inhibition activities

Three new xanthones, garcicowanones C-E (1 − 3), and six known xanthones (4 − 9) were isolated from the roots of Garcinia cowa Roxb. ex Choisy. Their chemical structures were determined using spectroscopic technics, including HR-ESI-MS and 2 D NMR. All isolated compounds were evaluated for in vitro...

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Bibliographic Details
Published in:Natural product research 2023-11, Vol.37 (21), p.3668-3676
Main Authors: An, Nguyen Thi Kim, Van Hien, Nguyen, Thi Thuy, Nguyen, Lan Phuong, Doan, Gia Bach, Ha, Tra, Nguyen Thanh, Quang Tung, Nguyen, Tham, Pham Thi, Tai, Bui Huu, Thu Thuy, Tran Thi
Format: Article
Language:English
Subjects:
Acarbose
antidiabetic activity
garcicowanone C
garcicowanone D
garcicowanone E
Garcinia
Garcinia cowa
Glucosidase
NMR
Nuclear magnetic resonance
Roots
α-Glucosidase
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Summary:Three new xanthones, garcicowanones C-E (1 − 3), and six known xanthones (4 − 9) were isolated from the roots of Garcinia cowa Roxb. ex Choisy. Their chemical structures were determined using spectroscopic technics, including HR-ESI-MS and 2 D NMR. All isolated compounds were evaluated for in vitro α-glucosidase inhibition. Cowanol (6) and norcowanin (8) had the most potent α-glucosidase inhibitory activity, with respective IC 50 values of 33.5 ± 0.8 and 17.2 ± 0.3 µM, compared with the positive control, acarbose (IC 50 257.3 ± 4.8 µM).
ISSN:1478-6419
1478-6427
DOI:10.1080/14786419.2022.2098956