Detection of magnetic iron nanoparticles by single-particle ICP-TOFMS: case study for a magnetic filtration medical device

Nanoparticles are increasingly used in medical products and devices. Their properties are critical for such applications, as particle characteristics determine their interaction with the biological system, and, therefore, the performance and safety of the final product. Among the most important nano...

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Bibliographic Details
Published in:Analytical and bioanalytical chemistry 2022-09, Vol.414 (23), p.6743-6751
Main Authors: Mehrabi, Kamyar, Dengler, Monika, Nilsson, Inga, Baumgartner, Manuel, Mora, Carlos A., Günther, Detlef, Gundlach-Graham, Alexander
Format: Article
Language:English
Subjects:
Analysis
Analytical Chemistry
Biochemistry
Blood
Calibration
Case studies
Cementite
Characterization and Evaluation of Materials
Chemistry
Chemistry and Materials Science
Food Science
Identification and classification
Inductively coupled plasma
Inductively coupled plasma mass spectrometry
Iron
Iron carbides
Laboratory Medicine
Magnetic properties
Mass distribution
Mass spectrometry
Mass spectroscopy
Medical electronics
Medical equipment
Methods
Monitoring/Environmental Analysis
Nanomaterials
Nanoparticles
Particle mass
Research Paper
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Summary:Nanoparticles are increasingly used in medical products and devices. Their properties are critical for such applications, as particle characteristics determine their interaction with the biological system, and, therefore, the performance and safety of the final product. Among the most important nanoparticle characteristics and parameters are particle mass distribution, composition, total particle mass, and number concentration. In this study, we utilize single-particle inductively coupled plasma time-of-flight mass spectrometry (spICP-TOFMS) for the characterization of inorganic nanoparticles in complex biological fluids. We report online microdroplet calibration for reference-nanomaterial-free and matrix-matched calibration of carbon-coated iron carbide nanoparticles (C/Fe 3 C NPs). As a case study, we analyze C/Fe 3 C NPs designed for targeted blood purification. Through the analysis of NP mass distributions, we study the effect of the NP surface modification on aggregation of C/Fe 3 C NPs in whole blood. We also demonstrate the efficiency of removal of coated C/Fe 3 C NP from saline by magnetically enhanced filters. Magnetic filtering is shown to reduce the mass concentration of detectable C/Fe 3 C NPs by 99.99 ± 0.01% in water. Graphical abstract
ISSN:1618-2642
1618-2650
DOI:10.1007/s00216-022-04234-w