Elevated 8-isoprostane concentration is associated with thromboembolic events in patients with atrial fibrillation

Enhanced oxidative stress occurs in atrial fibrillation (AF), however its impact on the efficacy and safety of anticoagulation is unknown. We sought to evaluate whether 8-isoprostaglandin F2 (8-isoprostane) levels are associated with clinical outcomes in anticoagulated AF patients. In a study involv...

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Bibliographic Details
Published in:International journal of cardiology 2022-10, Vol.365, p.1-7
Main Authors: Mołek, Patrycja, Chmiel, Jakub, Ząbczyk, Michał, Malinowski, Krzysztof P., Natorska, Joanna, Undas, Anetta
Format: Article
Language:English
Subjects:
Atrial fibrillation
Fibrin clot
Fibrinolysis
Isoprostanes
Stroke
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Summary:Enhanced oxidative stress occurs in atrial fibrillation (AF), however its impact on the efficacy and safety of anticoagulation is unknown. We sought to evaluate whether 8-isoprostaglandin F2 (8-isoprostane) levels are associated with clinical outcomes in anticoagulated AF patients. In a study involving 243 AF patients (median age 69 years), we measured serum 8-isoprostane, along with prothrombotic markers, including plasma fibrin clot permeability, clot lysis time (CLT), endogenous thrombin potential (ETP), von Willebrand factor (VWF), and fibrinolytic proteins. Ischemic cerebrovascular events, major bleeding, and death were recorded during a median follow-up of 53 months while on anticoagulation, largely on non-vitamin K antagonist oral anticoagulants (NOACs). Increased 8-isoprostane levels were observed in women, in patients with arterial hypertension, and those with paroxysmal or persistent AF. Patients with 8-isoprostane levels ≥559 pg/mL (the top quartile) compared with those with 8-isoprostane
ISSN:0167-5273
1874-1754
DOI:10.1016/j.ijcard.2022.07.034