Gastrointestinal helminths in dogs: occurrence, risk factors, and multiple antiparasitic drug resistance

• Published in: Parasitology research (1987) 2022-09, Vol.121 (9), p.2579-2586
• Main Authors: D’ambroso Fernandes, Fagner, Rojas Guerra, Renata, Segabinazzi Ries, Ananda, Felipetto Cargnelutti, Juliana, Sangioni, Luis Antonio, Silveira Flores Vogel, Fernanda
• Format: Article
• Language: English
• Subjects: Antiparasitic agents; Biomedical and Life Sciences; Biomedicine; Dogs; Drug resistance; Health aspects; Immunology; Infection; Infections; Medical Microbiology; Microbiology; Parasitism; Praziquantel; Pyrantel pamoate; Risk factors; Selamectin; Treatment and Prophylaxis - Original Paper
• ISSN: 0932-0113; 1432-1955
• DOI: 10.1007/s00436-022-07599-0

Helminth infections are detrimental to the overall health of dogs; therefore, this study aimed to identify antiparasitic-resistant helminths and evaluate the infection rate and risk factors for parasitism in canines. For this purpose, a parasitological evaluation of 38 randomly selected animals was performed, followed by the evaluation of the anthelminthic efficacy of three drugs: pyrantel pamoate with praziquantel (Canex Composto®), fenbendazole (Fenzol Pet®), and milbemycin oxime with praziquantel (Milbemax C®). Among the evaluated animals, 22/38 (57.89%) tested negative and 16/38 (42.71%) tested positive for Ancylostoma caninum infection. Evaluation of the efficacy of antiparasitic drugs showed that 12/16 (75%) dogs were infected with helminths that were susceptible to pyrantel pamoate with praziquantel. Among those for which pyrantel pamoate with praziquantel was not effective, 3/4 (75%) were susceptible to fenbendazole, while the remaining case resistant to both pyrantel pamoate with praziquantel and fenbendazole was sensitive to milbemycin oxime with praziquantel (100%). The odds ratio of infection in dogs inhabiting environments containing soil or grass was 6.67 times higher than that in dogs inhabiting impermeable environments. Mixed-breed dogs (SRD) were 6.54 times more likely to be infected compared to purebred dogs. A. caninum resistant to pyrantel pamoate with praziquantel (4/16, 25%) and fenbendazole (1/4, 25%) were detected. The results of this study demonstrated the importance of coproparasitological monitoring by professionals before and after treatments to assess antiparasitic drug effectiveness, ensure animal health and welfare, and minimize animal exposure to risk factors.