Impact of an estrogen replacement regimen on live birth rate in frozen–thawed good‐quality embryo transfer

• Published in: International journal of gynecology and obstetrics 2023-03, Vol.160 (3), p.829-835
• Main Authors: Şükür, Yavuz Emre, Aslan, Batuhan, Özmen, Batuhan, Sönmezer, Murat, Berker, Bülent, Atabekoğlu, Cem Somer, Aytaç, Ruşen, AliZahi, Saeed, Huseynli, Kamran, Moghaddam, Vefagh, Majidli, Aykhan, Gül, Dilay, Khalilzade, Emil, İleri, Melisa
• Format: Article
• Language: English
• Subjects: Birth Rate; Cryopreservation; Embryo Transfer; endometrial preparation; endometrial thickness; Endometrium; Estradiol; estrogen replacement; Estrogen Replacement Therapy; Estrogens; Female; frozen–thawed embryo transfer; Humans; in vitro fertilization; Infertility, Female; Live Birth; Pregnancy; Pregnancy Rate; Retrospective Studies
• ISSN: 0020-7292; 1879-3479
• DOI: 10.1002/ijgo.14366

Objective To assess the impact of an estrogen replacement regimen on frozen embryo transfer (FET) cycle outcome. Methods In the present retrospective cohort study, data of infertile women undergoing FET with good‐quality embryos were reviewed. The first group received 2 mg of estradiol hemihydrate (EH) once daily for 6 to 7 days, then twice daily for 4 to 5 days, and then three times a day until embryo transfer. The second group received EH twice daily for 7 to 8 days, then three times a day. The third group received EH three times a day constantly. The main outcome measure was live birth rate. Results In total, 394 FET cycles were included. The fixed 6‐mg group required the highest estradiol hemihydrate dose. The duration of estrogen treatment was significantly longer in the first group. Maximal endometrial thickness was highest in the second group (10.2 ± 1.3 mm vs. 9.6 ± 1.4 mm vs. 8.6 ± 0.9 mm, respectively; P