Effect of vitamin C supplementation on some leukocyte parameters in American mink (Neovison vison) with abnormal granulogenesis

Sapphire mink, a mutant colour variant of American mink, is an animal model of the Chediak-Higashi syndrome (CHS). As in CHS, there are enlarged cytoplasmic granules in various cell types including leukocytes in Sapphire mink due to abnormal granulogenesis. Such cellular abnormality leads to a weake...

Full description

Saved in:
Bibliographic Details
Published in:Tissue & cell 2022-08, Vol.77, p.101870-101870, Article 101870
Main Authors: Kizhina, Aleksandra, Pechorina, Elvira, Mikheeva, Vlada
Format: Article
Language:English
Subjects:
Chediak-Higashy syndrome
Leukocytes
Lysosomes
Vitamin C
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Sapphire mink, a mutant colour variant of American mink, is an animal model of the Chediak-Higashi syndrome (CHS). As in CHS, there are enlarged cytoplasmic granules in various cell types including leukocytes in Sapphire mink due to abnormal granulogenesis. Such cellular abnormality leads to a weakening of the immune defence as a consequence to the development of infections. A study with Sapphire mink and Standard mink was conducted to evaluate the immunostimulant effect of vitamin C (VC) supplementation (100 mg/day) on some leukocyte parameters. In the end of the 20-day treatment period, blood samples were collected to determine hematological (total and differential leukocyte counts, red blood cells (RBC) counts, and haemoglobin level) and cytochemical (activity and staining area of myeloperoxidase, eosinophilc peroxidase, alkaline phosphatase, and alpha naphthyl acetate esterase) parameters. The study showed that total leukocyte counts, segmented neutrophil counts, and monocyte counts were significantly (p 
ISSN:0040-8166
1532-3072
DOI:10.1016/j.tice.2022.101870