Preprostatic lymph nodes in prostate cancer hot or not? Impact on oncological outcome after radical prostatectomy

Objective To assess the impact of preprostatic lymph node invasion on prostate cancer patients’ outcome after radical prostatectomy. It is known that invasion of pelvic lymph nodes is associated with worse oncological outcome, but little is known about invasion of preprostatic lymph nodes. We hypoth...

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Bibliographic Details
Published in:World journal of urology 2022-09, Vol.40 (9), p.2231-2237
Main Authors: Korten, Michael, Pose, Randi M., Graefen, Markus, Tilki, Derya, Michl, Uwe, Knipper, Sophie, Beyer, Burkhard
Format: Article
Language:English
Subjects:
Cancer surgery
Lymph nodes
Lymphatic system
Medicine
Medicine & Public Health
Metastases
Nephrology
Oncology
Original Article
Patients
Prostate cancer
Prostatectomy
Robotic surgery
Statistical analysis
Urological surgery
Urology
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Summary:Objective To assess the impact of preprostatic lymph node invasion on prostate cancer patients’ outcome after radical prostatectomy. It is known that invasion of pelvic lymph nodes is associated with worse oncological outcome, but little is known about invasion of preprostatic lymph nodes. We hypothesized that positive preprostatic lymph nodes may not be as harmful as positive pelvic lymph nodes. Materials and methods A total of 11,107 consecutive patients treated for prostate cancer with radical prostatectomy between 2013 and 2017 were evaluated. 1575 (14.2%) had some type of lymph node invasion, 53 (0.5%) had only one positive preprostatic lymph node and 705 (6.3%) had only one positive pelvic lymph node. Results Median follow-up was 37.7 months (interquartile range: 24.6–58.7 months). Baseline characteristics of the overall cohort were not statistically significant between the preprostatic vs. pelvic lymph node invasion groups, except for robot-assisted operation (64.2 vs. 32.3%, p  
ISSN:1433-8726
0724-4983
1433-8726
DOI:10.1007/s00345-022-04103-2