Palladium-Catalyzed Intramolecular Heck/Aminocarbonylation of Alkene-Tethered Iodobenzenes with Nitro Compounds: Synthesis of Carbamoyl-Substituted Benzoheterocycles

A palladium-catalyzed intramolecular Heck/aminocarbonylation of alkene-tethered iodobenzenes with nitro compounds has been developed for the synthesis of carbamoyl-substituted benzoheterocycles. Using Mo­(CO)6 as a solid CO source, no external reductant or additives were needed in this procedure. Bo...

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Published in:Journal of organic chemistry 2023-04, Vol.88 (8), p.5097-5107
Main Authors: Kang, Yun, Lu, Jin-Liang, Zhang, Zhi, Liang, Ying-Kang, Ma, Ai-Jun, Peng, Jin-Bao
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cited_by cdi_FETCH-LOGICAL-a333t-c33380811727d5350e1cfff10561b61e6c0a74f2079868c5ac532ebcb58629313
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container_issue 8
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container_title Journal of organic chemistry
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creator Kang, Yun
Lu, Jin-Liang
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description A palladium-catalyzed intramolecular Heck/aminocarbonylation of alkene-tethered iodobenzenes with nitro compounds has been developed for the synthesis of carbamoyl-substituted benzoheterocycles. Using Mo­(CO)6 as a solid CO source, no external reductant or additives were needed in this procedure. Both nitroarenes and nitroalkanes were well tolerated. A range of carbamoyl-substituted dihydrobenzofurans and indolines were prepared in moderate to high yields.
doi_str_mv 10.1021/acs.joc.2c01253
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title Palladium-Catalyzed Intramolecular Heck/Aminocarbonylation of Alkene-Tethered Iodobenzenes with Nitro Compounds: Synthesis of Carbamoyl-Substituted Benzoheterocycles
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